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Brief Communications

Critical Period for Inhibitory Plasticity in RodentBinocular V1

Arianna Maffei, Mary E. Lambo and Gina G. Turrigiano
Journal of Neuroscience 3 March 2010, 30 (9) 3304-3309; https://doi.org/10.1523/JNEUROSCI.5340-09.2010
Arianna Maffei
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Mary E. Lambo
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Gina G. Turrigiano
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    Figure 1.

    MD does not affect mEPSCs in V1b. A, Sample traces of sham and monocularly deprived (Contra) mEPSCs. B–D, Cumulative data for mEPSC amplitude, decay, and frequency from sham (black) and Contra (gray) neurons.

  • Figure 2.
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    Figure 2.

    Opposite plasticity of mIPSCs in pre-CP and the CP. A, Sample traces for sham and monocularly deprived (Contra) neurons at different ages. B, Bar plot summarizing the effect of MD in development. Asterisks indicate significant differences. C, Bar plot summarizing the effect of DT on mIPSCs. D, Cumulative distribution of mIPSC amplitudes for P25 control and DT rats.

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    Figure 3.

    Pre-CP effect of MD on mIPSCs. A, Ranked distribution of mIPSC amplitude in sham (black solid), sham-Zolpidem (sham Zol; black dotted), monocularly deprived (contra; gray solid), and monocularly deprived-Zolpidem (contra Zol; gray dotted) animals. B, Bar plots summarizing changes in mIPSC amplitude (in picoamperes) and decay (in milliseconds) induced by Zolpidem in sham (black) and monocularly deprived (gray). C, Bar plot showing the percentage of neurons sensitive to Zolpidem (Zol+) and of bimodal neurons in sham (black) and monocularly deprived (gray). D, Distribution of mIPSC amplitude in sham (bin, 2 pA; top) and sham-Zolpidem (bottom). E, Distribution of mIPSC amplitude in monocularly deprived (top) and monocularly deprived-Zolpidem (bottom). Gray shades indicate peaks in the sham distribution in D. Asterisks indicate significant differences.

  • Figure 4.
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    Figure 4.

    CP effect of MD on mIPSCs. A, Ranked distribution of mIPSC amplitude in sham (black solid), sham-Zolpidem (sham-Zol; black dotted), monocularly deprived (contra; gray), and monocularly deprived-Zolpidem (contra Zol; gray dotted) animals. B, Bar plots with changes in mIPSC amplitude (in picoamperes) and decay (in milliseconds) induced by Zolpidem in sham (black) and monocularly deprived (gray). C, Bar plot showing the percentage of neurons sensitive to Zolpidem (Zol+) and of bimodal neurons in sham (black) and monocularly deprived (gray). D, Distribution of mIPSC amplitude in sham (top) and sham-Zolpidem (bottom). E, Distribution of mIPSC amplitude in monocularly deprived (top) and monocularly deprived-Zolpidem (bottom). Gray shades indicate peaks in the sham distribution in D. Asterisks indicate significant differences.

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The Journal of Neuroscience: 30 (9)
Journal of Neuroscience
Vol. 30, Issue 9
3 Mar 2010
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Critical Period for Inhibitory Plasticity in RodentBinocular V1
Arianna Maffei, Mary E. Lambo, Gina G. Turrigiano
Journal of Neuroscience 3 March 2010, 30 (9) 3304-3309; DOI: 10.1523/JNEUROSCI.5340-09.2010

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Critical Period for Inhibitory Plasticity in RodentBinocular V1
Arianna Maffei, Mary E. Lambo, Gina G. Turrigiano
Journal of Neuroscience 3 March 2010, 30 (9) 3304-3309; DOI: 10.1523/JNEUROSCI.5340-09.2010
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