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Articles, Behavioral/Systems/Cognitive

Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation

Fadel Zeidan, Katherine T. Martucci, Robert A. Kraft, Nakia S. Gordon, John G. McHaffie and Robert C. Coghill
Journal of Neuroscience 6 April 2011, 31 (14) 5540-5548; https://doi.org/10.1523/JNEUROSCI.5791-10.2011
Fadel Zeidan
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Katherine T. Martucci
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Robert A. Kraft
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Nakia S. Gordon
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John G. McHaffie
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Robert C. Coghill
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5791-10.2011
PubMed 
21471390
Published By 
Society for Neuroscience
History 
  • Received November 3, 2010
  • Revision received January 6, 2011
  • Accepted February 13, 2011
  • First published April 6, 2011.
  • Version of record published April 6, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/315540-09$15.00/0

Author Information

  1. Fadel Zeidan1,
  2. Katherine T. Martucci1,
  3. Robert A. Kraft2,
  4. Nakia S. Gordon3,
  5. John G. McHaffie1, and
  6. Robert C. Coghill1
  1. 1Departments of Neurobiology and Anatomy and
  2. 2Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, and
  3. 3Psychology Department, Marquette University, Milwaukee, Wisconsin 53233
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Author contributions

Disclosures

    • Received November 3, 2010.
    • Revision received January 6, 2011.
    • Accepted February 13, 2011.
  • This study was supported by the Mind and Life Institute Varela Grant, National Institutes of Health Grant NS39426, and the Center for Biomolecular Imaging of Wake Forest University School of Medicine.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Fadel Zeidan, Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. fzeidan{at}wfubmc.edu

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Total153083511310175
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The Journal of Neuroscience: 31 (14)
Journal of Neuroscience
Vol. 31, Issue 14
6 Apr 2011
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Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
Fadel Zeidan, Katherine T. Martucci, Robert A. Kraft, Nakia S. Gordon, John G. McHaffie, Robert C. Coghill
Journal of Neuroscience 6 April 2011, 31 (14) 5540-5548; DOI: 10.1523/JNEUROSCI.5791-10.2011

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Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
Fadel Zeidan, Katherine T. Martucci, Robert A. Kraft, Nakia S. Gordon, John G. McHaffie, Robert C. Coghill
Journal of Neuroscience 6 April 2011, 31 (14) 5540-5548; DOI: 10.1523/JNEUROSCI.5791-10.2011
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  • Meditation Increases DHEA more than the Placebo Effect
    James M Howard
    Published on: 19 November 2015
  • Published on: (19 November 2015)
    Page navigation anchor for Meditation Increases DHEA more than the Placebo Effect
    Meditation Increases DHEA more than the Placebo Effect
    • James M Howard, Biologist

    The basis of the results in this report might be increased dehydroepiandrosterone (DHEA). It is known that mindfulness / meditation increases DHEA (Glaser et al., 1992; Manzaneque et al., 2011).

    It is my hypothesis that the placebo effect results from increased DHEA. Possible Explanation of Failure to Thrive Infants May Have a Reduced Melatonin -- DHEA Cycle"...a basis of the placebo effect. at: http://anthropo...

    Show More

    The basis of the results in this report might be increased dehydroepiandrosterone (DHEA). It is known that mindfulness / meditation increases DHEA (Glaser et al., 1992; Manzaneque et al., 2011).

    It is my hypothesis that the placebo effect results from increased DHEA. Possible Explanation of Failure to Thrive Infants May Have a Reduced Melatonin -- DHEA Cycle"...a basis of the placebo effect. at: http://anthropogeny.com/Failure%20to%20Thrive.htm.

    Meditation may simply produce more DHEA than the placebo effect because meditation is a targeted, practiced method of specifically increasing dehydroepiandrosterone.

    References

    Glaser JL, Brind JL, Vogelman JH, Eisner MJ, Dillbeck MC, Wallace RK, Chopra D, Orentreich N. Elevated serum dehydroepiandrosterone sulfate levels in practitioners of the Transcendental Meditation (TM) and TM-Sidhi programs. J Behav Med. 1992 Aug;15(4):327-41.

    Manzaneque, J. M., Vera, F. M., Ramos, N. S., Godoy, Y. A., Rodriguez, F. M., Blanca, M. J., Fernandez, A. and Enguix, A. (2011), Psychobiological modulation in anxious and depressed patients after a mindfulness meditation programme: a pilot study. Stress and Health, 27: 216???222

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.

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