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The Development of Female Sexual Behavior Requires Prepubertal Estradiol

Olivier Brock, Michael J. Baum and Julie Bakker
Journal of Neuroscience 13 April 2011, 31 (15) 5574-5578; DOI: https://doi.org/10.1523/JNEUROSCI.0209-11.2011
Olivier Brock
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Michael J. Baum
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Julie Bakker
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    Figure 1.

    Effect of early postnatal (A; P5–P15) or prepubertal (B; P15–P25) EB treatment of WT and ArKO female mice on the expression of lordosis behavior in adulthood following ovariectomy and treatment with ovarian hormones. Mean ± SEM lordosis quotients over consecutive tests in WT control females, WT females treated with EB, ArKO control females, and ArKO females treated with EB are shown. A, Values for WT control females on test 3 were significantly higher than values for the other 3 groups of female mice (*p < 0.05) by post hoc tests. B, Values for the ArKO control females on tests 5 and 6 were significantly lower than values for the other 3 groups of female mice (*p < 0.05) by post hoc tests. The number of female mice in each group is given in parentheses.

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    Figure 2.

    Effect of early postnatal (A; P5–P15) or prepubertal (B; P15–P25) EB treatment of WT and ArKO female mice on the later display of female-directed mounting behavior in adulthood following ovariectomy and treatment with testosterone. Mean ± SEM numbers of mounts displayed by WT control females, WT females treated with EB, ArKO control females, and ArKO females treated with EB are shown. Means with different superscript letters are significantly different from each other by post hoc comparisons (p < 0.05). The number of female mice in each group is given in parentheses.

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    Figure 3.

    Effect of prepubertal (P15–P25) EB treatment of WT and ArKO females on mate preference in adulthood following ovariectomy and treatment with ovarian hormones. Shown are mean ± SEM times spent by WT control females, WT females treated prepubertally with EB, ArKO control females, and ArKO females treated prepubertally with EB investigating the compartment containing an intact male versus an estrous female. *p < 0.05, post hoc comparisons of time spent investigating the two types of stimulus animals. The number of female mice in each group is given in parentheses.

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The Journal of Neuroscience: 31 (15)
Journal of Neuroscience
Vol. 31, Issue 15
13 Apr 2011
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The Development of Female Sexual Behavior Requires Prepubertal Estradiol
Olivier Brock, Michael J. Baum, Julie Bakker
Journal of Neuroscience 13 April 2011, 31 (15) 5574-5578; DOI: 10.1523/JNEUROSCI.0209-11.2011

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The Development of Female Sexual Behavior Requires Prepubertal Estradiol
Olivier Brock, Michael J. Baum, Julie Bakker
Journal of Neuroscience 13 April 2011, 31 (15) 5574-5578; DOI: 10.1523/JNEUROSCI.0209-11.2011
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