Figure 1. Aβ-induced LTP impairments are rescued by EUK134 and MitoQ. A, HFS induced LTP in vehicle-treated slices (black triangles, n = 7), but not in slices pretreated with 500 nm Aβ1-42 (gray triangles, n = 9). In contrast, Aβ1-42 treatment did not inhibit LTP in the presence of either EUK134 (250 nm, dark gray circles, n = 6) or MitoQ (500 nm, light gray hexagons, n = 8). The dashed line represents the normalized baseline value of 100%. B, Compared with vehicle-treated slices (gray diamonds, n = 10), either 500 nm MitoQ (black triangles, n = 7), or 250 nm EUK134 (gray circles, n = 7) alone did not have an effect on LTP. In addition, treatment of slices with either EUK134 (gray hexagons, n = 10) or MitoQ (black hexagons, n = 9) did not affect baseline fEPSPs. C, Cumulative data showing mean fEPSP slopes 80 min post-HFS based on the LTP experiments in A and B. D, HFS-induced LTP was expressed normally in slices treated with scrambled Aβ1-42 peptide (500 nm, n = 5). sc, Scrambled.