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Articles, Neurobiology of Disease

Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model

Kang-Woo Lee, Walter Chen, Eunsung Junn, Joo-Young Im, Hilary Grosso, Patricia K. Sonsalla, Xuyan Feng, Neelanjana Ray, Jose R. Fernandez, Yang Chao, Eliezer Masliah, Michael Voronkov, Steven P. Braithwaite, Jeffry B. Stock and M. Maral Mouradian
Journal of Neuroscience 11 May 2011, 31 (19) 6963-6971; https://doi.org/10.1523/JNEUROSCI.6513-10.2011
Kang-Woo Lee
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Walter Chen
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Eunsung Junn
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Joo-Young Im
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Hilary Grosso
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Patricia K. Sonsalla
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Xuyan Feng
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Neelanjana Ray
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Jose R. Fernandez
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Yang Chao
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Eliezer Masliah
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Michael Voronkov
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Steven P. Braithwaite
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Jeffry B. Stock
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M. Maral Mouradian
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.6513-10.2011
PubMed 
21562258
Published By 
Society for Neuroscience
History 
  • Received December 14, 2010
  • Revision received March 10, 2011
  • Accepted March 16, 2011
  • First published May 11, 2011.
  • Version of record published May 11, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/316963-09$15.00/0 This article is freely available online through the J Neurosci Open Choice option.

Author Information

  1. Kang-Woo Lee1,
  2. Walter Chen2,
  3. Eunsung Junn1,
  4. Joo-Young Im1,
  5. Hilary Grosso1,
  6. Patricia K. Sonsalla1,
  7. Xuyan Feng3,
  8. Neelanjana Ray3,
  9. Jose R. Fernandez3,
  10. Yang Chao3,
  11. Eliezer Masliah4,
  12. Michael Voronkov3,
  13. Steven P. Braithwaite3,
  14. Jeffry B. Stock2,3, and
  15. M. Maral Mouradian1
  1. 1Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854,
  2. 2Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544,
  3. 3Signum Biosciences, Monmouth Junction, New Jersey 08852, and
  4. 4Department of Neurosciences, School of Medicine, University of California-San Diego, La Jolla, California, 92093
View Full Text

Author contributions

  1. Author contributions: J.B.S. and M.M.M. designed research; K.-W.L., W.C., J.-Y.I., H.G., P.K.S., X.F., N.R., J.R.F., Y.C., and M.V. performed research; E.M. contributed unpublished reagents/analytic tools; K.-W.L., E.J., J.-Y.I., S.P.B., J.B.S., and M.M.M. analyzed data; S.P.B., J.B.S., and M.M.M. wrote the paper.

Disclosures

    • Received December 14, 2010.
    • Revision received March 10, 2011.
    • Accepted March 16, 2011.
  • J.B.S. is a founder of Signum Biosciences, Inc., which employs the indicated coauthors.

  • This work was supported by a grant from Signum Biosciences to M.M.M., who is the William Dow Lovett Professor of Neurology. J.B.S. is supported in part by a grant from the American Parkinson Disease Association. We thank Teresa Chan for technical assistance and Yulia Frenkel for manuscript preparation.

  • Correspondence should be addressed to Dr. M. Maral Mouradian, Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, Piscataway, NJ 08854. Mouradian{at}umdnj.edu

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Total51354601268
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The Journal of Neuroscience: 31 (19)
Journal of Neuroscience
Vol. 31, Issue 19
11 May 2011
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Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model
Kang-Woo Lee, Walter Chen, Eunsung Junn, Joo-Young Im, Hilary Grosso, Patricia K. Sonsalla, Xuyan Feng, Neelanjana Ray, Jose R. Fernandez, Yang Chao, Eliezer Masliah, Michael Voronkov, Steven P. Braithwaite, Jeffry B. Stock, M. Maral Mouradian
Journal of Neuroscience 11 May 2011, 31 (19) 6963-6971; DOI: 10.1523/JNEUROSCI.6513-10.2011

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Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model
Kang-Woo Lee, Walter Chen, Eunsung Junn, Joo-Young Im, Hilary Grosso, Patricia K. Sonsalla, Xuyan Feng, Neelanjana Ray, Jose R. Fernandez, Yang Chao, Eliezer Masliah, Michael Voronkov, Steven P. Braithwaite, Jeffry B. Stock, M. Maral Mouradian
Journal of Neuroscience 11 May 2011, 31 (19) 6963-6971; DOI: 10.1523/JNEUROSCI.6513-10.2011
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