Article Figures & Data
Figures
- Figure 1.
Acquisition, extinction, and reacquisition of 2-AG self-administration behavior over consecutive sessions. A, B, Acquisition: number of injections per session (A) and overall rates of responding (B) in the presence of a green light during 30 μg/kg/injection anandamide sessions (sessions 1–5, closed circles), vehicle sessions (sessions 6–10, open circles), and 2-AG 3 μg/kg/injection sessions (sessions 11–15, closed circles) are shown. C, D, Extinction and reacquisition: number of injections per session (C) and overall rates of responding (D) during 30 μg/kg/injection 2-AG sessions (sessions 1–5, closed circles), vehicle sessions (sessions 6–9, open circles), and 2-AG 1 μg/kg/injection sessions (sessions 10–13, closed circles) are shown. Points represent means ± SEM from four subjects. **p < 0.01, post hoc comparisons with the last session before vehicle extinction (session 5).
- Figure 2.
2-AG self-administration in nicotine-experienced monkeys over consecutive sessions. A, B, Number of injections per session (A) and overall rates of responding (B) in the presence of a green light during 30 μg/kg/injection nicotine sessions (sessions 1–5, closed circles), vehicle sessions (sessions 6–10, open circles), and 2-AG 3 μg/kg/injection sessions (sessions 11–15, closed circles) are shown. Points represent means ± SEM from four subjects. **p < 0.01, post hoc comparisons with the last session before vehicle extinction (session 5).
- Figure 3.
Effects of varying injection dose on self-administration of 2-AG. A–C, Number of injections of 2-AG per session (A), overall rates of responding in the presence of the green light signaling 2-AG availability (B), and total 2-AG intake per session (C) are shown as a function of injection dose of drug. Each point represents the mean ± SEM (n = 4) of the last three sessions under each 2-AG unit dose condition and under a vehicle condition. **p < 0.01 post hoc comparisons with the vehicle conditions. V, Vehicle.
- Figure 4.
Effects of rimonabant given as a pretreatment before experimental session on responding maintained by 2-AG (A), THC (B), or food (C) during five consecutive sessions. A–C, Numbers of injections per session after intramuscular pretreatment with vehicle (sessions 1–3 and 9–11, closed circles,) or 0.3 mg/kg rimonabant (sessions 4–8, open circles) are shown. Each point represents the mean ± SEM from three (A), five (B), or four (C) monkeys. **p < 0.01, post hoc comparisons with the last session with vehicle pretreatment (session 3) before pretreatment with rimonabant.
