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Featured ArticleArticles, Development/Plasticity/Repair

Neuroligin 2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction

Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne and Wei Xie
Journal of Neuroscience 12 January 2011, 31 (2) 687-699; DOI: https://doi.org/10.1523/JNEUROSCI.3854-10.2011
Mingkuan Sun
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Guanglin Xing
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Liudi Yuan
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Guangming Gan
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David Knight
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Sheila Irene With
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Cui He
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Junhai Han
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Xiankun Zeng
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Ming Fang
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Gabrielle L. Boulianne
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Wei Xie
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3854-10.2011
PubMed 
21228178
Published By 
Society for Neuroscience
History 
  • Received July 22, 2010
  • Revision received September 12, 2010
  • Accepted October 26, 2010
  • First published January 12, 2011.
  • Version of record published January 12, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/310687-13$15.00/0

Author Information

  1. Mingkuan Sun 1 , 2 ,
  2. Guanglin Xing 1 , 2 ,
  3. Liudi Yuan 1 , 3 ,
  4. Guangming Gan 1 , 2 ,
  5. David Knight 4 ,
  6. Sheila Irene With 4 ,
  7. Cui He 1 , 2 ,
  8. Junhai Han 1 , 2 ,
  9. Xiankun Zeng 2 ,
  10. Ming Fang 1 , 2 ,
  11. Gabrielle L. Boulianne 4 , and
  12. Wei Xie 1 , 2
  1. 1The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China,
  2. 2Departments of Medical Genetics and Developmental Biology and
  3. 3Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing 210009, China, and
  4. 4Program in Developmental and Stem Cell Biology, The Hospital for Sick Children and Department Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5G 1L7
  1. Correspondence should be addressed to either of the following: Gabrielle L. Boulianne or Wei Xie, Toronto Medical Discovery Tower, 12th Floor, East Tower, 101 College Street, Toronto, Ontario, Canada M5G 1L7, gboul{at}sickkids.ca; Wei Xie, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China, E-mail: wei.xie{at}seu.edu.cn
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Author contributions

Disclosures

    • Received July 22, 2010.
    • Revision received September 12, 2010.
    • Accepted October 26, 2010.
  • This work was supported by Natural Science Foundation of China Grant 30370698, Key Grant of Ministry of Education Grant 03083, National Basic Research Program (973 Program) Grant 2005CB522501, Foundation for Excellent Doctoral Dissertation of Southeast University Grant YBJJ0520, the Open Research Fund of Jiangsu Key Laboratory of Neurodegeneration, and Canadian Institutes for Health Research Grant MOP 14143. G.L.B. is the recipient of a Tier I Canada Research Chair in Molecular and Developmental Neurobiology. We thank Drs. Zhengping Jia, William Trimble, and Mei Zhen for useful discussions and critical comments on this manuscript. We also thank Dr. Yongqing Zhang for technical assistance with the electrophysiology experiments, Dr. Xun Huang for technical assistance with gene targeting, Dr. Chunjie Zhao for helpful suggestions, and Jinjun Qian for help with bioinformatics. We are grateful to Dr. A. DiAntonio for anti-DGluR antibodies, Dr. N. Harden for anti-DPAK antibody, and the Bloomington Stock Center for providing Drosophila stocks.

  • Correspondence should be addressed to either of the following: Gabrielle L. Boulianne or Wei Xie, Toronto Medical Discovery Tower, 12th Floor, East Tower, 101 College Street, Toronto, Ontario, Canada M5G 1L7, gboul{at}sickkids.ca; Wei Xie, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China, E-mail: wei.xie{at}seu.edu.cn

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The Journal of Neuroscience: 31 (2)
Journal of Neuroscience
Vol. 31, Issue 2
12 Jan 2011
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Neuroligin 2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction
Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne, Wei Xie
Journal of Neuroscience 12 January 2011, 31 (2) 687-699; DOI: 10.1523/JNEUROSCI.3854-10.2011

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Neuroligin 2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction
Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne, Wei Xie
Journal of Neuroscience 12 January 2011, 31 (2) 687-699; DOI: 10.1523/JNEUROSCI.3854-10.2011
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