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Articles, Behavioral/Systems/Cognitive

Ventromedial Frontal Lobe Damage Disrupts Value Maximization in Humans

Nathalie Camille, Cathryn A. Griffiths, Khoi Vo, Lesley K. Fellows and Joseph W. Kable
Journal of Neuroscience 18 May 2011, 31 (20) 7527-7532; DOI: https://doi.org/10.1523/JNEUROSCI.6527-10.2011
Nathalie Camille
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Cathryn A. Griffiths
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Khoi Vo
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Lesley K. Fellows
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Joseph W. Kable
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Abstract

Recent work in neuroeconomics has shown that regions in orbitofrontal and medial prefrontal cortex encode the subjective value of different options during choice. However, these electrophysiological and neuroimaging studies cannot demonstrate whether such signals are necessary for value-maximizing choices. Here we used a paradigm developed in experimental economics to empirically measure and quantify violations of utility theory in humans with damage to the ventromedial frontal lobe (VMF). We show that people with such damage are more likely to make choices that violate the generalized axiom of revealed preference, which is the one necessary and sufficient condition for choices to be consistent with value maximization. These results demonstrate that the VMF plays a critical role in value-maximizing choice.

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The Journal of Neuroscience: 31 (20)
Journal of Neuroscience
Vol. 31, Issue 20
18 May 2011
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Ventromedial Frontal Lobe Damage Disrupts Value Maximization in Humans
Nathalie Camille, Cathryn A. Griffiths, Khoi Vo, Lesley K. Fellows, Joseph W. Kable
Journal of Neuroscience 18 May 2011, 31 (20) 7527-7532; DOI: 10.1523/JNEUROSCI.6527-10.2011

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Ventromedial Frontal Lobe Damage Disrupts Value Maximization in Humans
Nathalie Camille, Cathryn A. Griffiths, Khoi Vo, Lesley K. Fellows, Joseph W. Kable
Journal of Neuroscience 18 May 2011, 31 (20) 7527-7532; DOI: 10.1523/JNEUROSCI.6527-10.2011
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