Cover legend: Three-dimensional reconstruction of an ∼100 μm² segment of vestibular sensory epithelium from the saccular macula, viewed from the apical surface. Tenascin-C (red), an extracellular matrix protein, fills much of the synaptic cleft between type I hair cells and their respective calyceal or cup-like afferent contacts. Small patches lacking immunoreactivity are observed at the base of each cup. Calretinin (green), a calcium-binding protein, labels type II cells (green spheres between the tenascin-filled synaptic clefts) and calyces belonging to a particular class of vestibular afferents (yellow circles corresponding to colocalization of tenascin-C and calretinin). Several complex calyx endings enclosing two or more type I hair cells can be seen, including one triple at the bottom center. For more information, see the article by Lysakowski et al. in this issue (pages 10101–10114).