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Featured ArticleArticles, Cellular/Molecular

Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors

Kasper Harpsøe, Philip K. Ahring, Jeppe K. Christensen, Marianne L. Jensen, Dan Peters and Thomas Balle
Journal of Neuroscience 27 July 2011, 31 (30) 10759-10766; DOI: https://doi.org/10.1523/JNEUROSCI.1509-11.2011
Kasper Harpsøe
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Philip K. Ahring
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Jeppe K. Christensen
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Marianne L. Jensen
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Dan Peters
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Thomas Balle
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1509-11.2011
PubMed 
21795528
Published By 
Society for Neuroscience
History 
  • Received March 25, 2011
  • Revision received May 11, 2011
  • Accepted May 27, 2011
  • First published July 27, 2011.
  • Version of record published July 27, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/3110759-08$15.00/0

Author Information

  1. Kasper Harpsøe1,*,
  2. Philip K. Ahring2,*,
  3. Jeppe K. Christensen2,
  4. Marianne L. Jensen2,
  5. Dan Peters2, and
  6. Thomas Balle1
  1. 1Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark, and
  2. 2NeuroSearch A/S, DK-2750 Ballerup, Denmark
View Full Text

Author contributions

  1. Author contributions: K.H., P.K.A., and T.B. designed research; K.H., P.K.A., and M.L.J. performed research; D.P. contributed unpublished reagents/analytic tools; K.H., P.K.A., J.K.C., and T.B. analyzed data; K.H., P.K.A., and T.B. wrote the paper.

  2. ↵*K.H. and P.K.A. contributed equally to this work.

Disclosures

    • Received March 25, 2011.
    • Revision received May 11, 2011.
    • Accepted May 27, 2011.
  • The authors declare no competing financial interests.

  • This work was supported in part by grants from the Lundbeck Foundation (T.B.), the Carlsberg Foundation (T.B., K.H.), and the Drug Research Academy, Faculty of Pharmaceutical Sciences, University of Copenhagen (K.H.). We thank Camilla Irlind and Lene G. Larsen from NeuroSearch A/S for expert technical assistance.

  • Correspondence should be addressed to Thomas Balle, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark. tb{at}farma.ku.dk

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In this issue

The Journal of Neuroscience: 31 (30)
Journal of Neuroscience
Vol. 31, Issue 30
27 Jul 2011
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Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors
Kasper Harpsøe, Philip K. Ahring, Jeppe K. Christensen, Marianne L. Jensen, Dan Peters, Thomas Balle
Journal of Neuroscience 27 July 2011, 31 (30) 10759-10766; DOI: 10.1523/JNEUROSCI.1509-11.2011

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Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors
Kasper Harpsøe, Philip K. Ahring, Jeppe K. Christensen, Marianne L. Jensen, Dan Peters, Thomas Balle
Journal of Neuroscience 27 July 2011, 31 (30) 10759-10766; DOI: 10.1523/JNEUROSCI.1509-11.2011
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