Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice

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¹Department of Neuroscience, Unit of Developmental Genetics, Uppsala University, S-751 24 Uppsala, Sweden,
²Faculty of Pharmacy and
³Departments of Pathology and Cell Biology and of Physiology, CNS Research Group, Faculty of Medicine, Université de Montréal, Montréal, H3C 3J7 Quebec, Canada,
⁴Department of Psychopharmacology, Central Institute of Mental Health, 68159 Mannheim, Germany,
⁵Department of Pharmacology, CNS Research Group, Faculty of Medicine, Université de Montréal, Montréal, H3C 3J7 Quebec, Canada, and
⁶Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden

Author contributions: J.A., C.B., B.H., D.L., and Å.W.-M. designed research; J.A., K.N., E.A., C.B., S.M., B.H., G.M.F., and Å.W.-M. performed research; L.O., K.K., and D.L. contributed unpublished reagents/analytic tools; J.A., K.N., E.A., C.B., S.M., C.S., G.M.F., L.O., L.D., L.-E.T., K.K., D.L., and Å.W.-M. analyzed data; J.A., B.H., C.S., L.O., L.D., L.-E.T., K.K., D.L., and Å.W.-M. wrote the paper.

This work was supported by grants from the Swedish Research Council Medicine (2007-5742/3630/4479, 2010-4394, 03185-39), The National Board of Health and Welfare (Socialstyrelsen), The Swedish Foundation for International Cooperation in Research and Higher Education, Uppsala University, the Swedish Brain Foundation, Swedish Brain Power, and the foundations of Hållsten, Göran Gustafsson, Åke Wiberg, and Åhlén, Sweden. J.A. was partly supported by the Swedish Academy of Pharmaceutical Sciences. Fonds de la Recherche en Santé du Québec provided infrastructure funding (Groupe de Recherche sur le Système Nerveux Central) to L.D. and L.-E.T. K.K. is a Royal Swedish Academy of Sciences Research Fellow supported by a grant from the Knut and Alice Wallenberg Foundation. We thank Prof. N.-G. Larsson for sharing the DAT-Cre mouse line, Dr. M. Lundblad and Prof. G. A. Gerhardt for sharing their expertise in in vivo amperometry, and Prof. S. El Mestikawy for critical reading of this manuscript.
L.O. is co-owner of a company owning the commercial rights to a genetic mouse model of Parkinson's disease, the generation of which requires use of the DAT-Cre mouse. No other potential conflicts of interest were reported.
Correspondence should be addressed to Åsa Wallén-Mackenzie, Department of Neuroscience, Unit of Developmental Genetics, Biomedical Center, P.O. Box 593, Uppsala University, S-751 24 Uppsala, Sweden. asa.mackenzie{at}neuro.uu.se

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