Cover legend: Pseudocolored image of immunofluorescent labeling of neurons (NeuN, red) and astrocytes (GFAP, blue) in the hippocampal CA1 pyramidal cell layer of transgenic mice overexpressing truncated amyloid-β. In these animals, formation of a highly neurotoxic amyloid-β species, pyro-Glu-Aβ, induces progressing astrogliosis and neuronal loss. For more information, see the article by Alexandru et al. in this issue (pages 12790–12801).