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Featured ArticleArticles, Neurobiology of Disease

Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants

Nelina Ramanantsoa, Marie-Rose Hirsch, Muriel Thoby-Brisson, Véronique Dubreuil, Julien Bouvier, Pierre-Louis Ruffault, Boris Matrot, Gilles Fortin, Jean-François Brunet, Jorge Gallego and Christo Goridis
Journal of Neuroscience 7 September 2011, 31 (36) 12880-12888; https://doi.org/10.1523/JNEUROSCI.1721-11.2011
Nelina Ramanantsoa
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Marie-Rose Hirsch
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Muriel Thoby-Brisson
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Véronique Dubreuil
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Julien Bouvier
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Pierre-Louis Ruffault
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Boris Matrot
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Gilles Fortin
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Jean-François Brunet
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Jorge Gallego
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Christo Goridis
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1721-11.2011
PubMed 
21900566
Published By 
Society for Neuroscience
History 
  • Received April 6, 2011
  • Revision received July 2, 2011
  • Accepted July 7, 2011
  • First published September 7, 2011.
  • Version of record published September 7, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/3112880-09$15.00/0

Author Information

  1. Nelina Ramanantsoa1,2,
  2. Marie-Rose Hirsch3,4,5,
  3. Muriel Thoby-Brisson6,
  4. Véronique Dubreuil3,4,5,
  5. Julien Bouvier6,
  6. Pierre-Louis Ruffault6,
  7. Boris Matrot1,2,
  8. Gilles Fortin6,
  9. Jean-François Brunet3,4,5,
  10. Jorge Gallego1,2, and
  11. Christo Goridis3,4,5
  1. 1Institut National de la Santé et de la Recherche Médicale (INSERM) U676, Hôpital Robert Debré, 75019 Paris, France,
  2. 2Université Denis Diderot, 75013 Paris, France,
  3. 3Ecole normale supérieure, Institut de Biologie, 75005 Paris, France,
  4. 4CNRS UMR8197, 75005 Paris, France,
  5. 5INSERM U1024, 75005 Paris, France, and
  6. 6Institut de Neurobiologie Alfred Fessard, CNRS UPR3294, 91198 Gif-sur-Yvette, France
  • M. Thoby-Brisson's present address: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Université Bordeaux, CNRS UMR 5287, 33076 Bordeaux, France.

  • V. Dubreuil's present address: UMR7216 Epigénétique et Destin Cellulaire, CNRS, Université Paris Diderot, 75013 Paris, France.

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Author contributions

  1. Author contributions: G.F., J.-F.B., J.G., and C.G. designed research; N.R., M.-R.H., M.-T.B., V.D., J.B., P.-L.R., B.M., and C.G. performed research; N.R., M.-R.H., M.-T.B., V.D., G.F., and J.G. analyzed data; C.G. wrote the paper.

  • M. Thoby-Brisson's present address: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Université Bordeaux, CNRS UMR 5287, 33076 Bordeaux, France.

  • V. Dubreuil's present address: UMR7216 Epigénétique et Destin Cellulaire, CNRS, Université Paris Diderot, 75013 Paris, France.

Disclosures

    • Received April 6, 2011.
    • Revision received July 2, 2011.
    • Accepted July 7, 2011.
  • This work was supported by grants from Agence Nationale de la Recherche (to J.F.B. and G.F.), Association Française du Syndrome d'Ondine (to J.G.), and Fondation pour la Recherche Médicale (to J.F.B.), and by institutional support from CNRS, INSERM, and Ecole normale supérieure. We thank Alexandre Pattyn for help in the initial stages of this work, and Carmen Le Moal and Sevrine Larney for expert animal husbandry. The founders of the mutant line were produced by the Mouse Clinical Institute, Illkirch, France.

  • Correspondence should be addressed to Christo Goridis or Jean-François Brunet, Institut de Biologie de l'Ecole normale supérieure, 46 Rue d'Ulm, 75005 Paris, France, goridis{at}biologie.ens.fr or jfbrunet{at}biologie.ens.fr; or to Jorge Gallego, InsermU676, Hôpital Robert Debré, 48 bd Sérurier, 75019 Paris, France, Jorge.Gallego{at}inserm.fr

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The Journal of Neuroscience: 31 (36)
Journal of Neuroscience
Vol. 31, Issue 36
7 Sep 2011
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Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants
Nelina Ramanantsoa, Marie-Rose Hirsch, Muriel Thoby-Brisson, Véronique Dubreuil, Julien Bouvier, Pierre-Louis Ruffault, Boris Matrot, Gilles Fortin, Jean-François Brunet, Jorge Gallego, Christo Goridis
Journal of Neuroscience 7 September 2011, 31 (36) 12880-12888; DOI: 10.1523/JNEUROSCI.1721-11.2011

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Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants
Nelina Ramanantsoa, Marie-Rose Hirsch, Muriel Thoby-Brisson, Véronique Dubreuil, Julien Bouvier, Pierre-Louis Ruffault, Boris Matrot, Gilles Fortin, Jean-François Brunet, Jorge Gallego, Christo Goridis
Journal of Neuroscience 7 September 2011, 31 (36) 12880-12888; DOI: 10.1523/JNEUROSCI.1721-11.2011
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