Discrete Neuroanatomical Networks Are Associated with Specific Cognitive Abilities in Old Age

Wei Wen; Wanlin Zhu; Yong He; Nicole A. Kochan; Simone Reppermund; Melissa J. Slavin; Henry Brodaty; John Crawford; Aihua Xia; Perminder Sachdev

doi:10.1523/JNEUROSCI.4085-10.2011

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Figure 1.
Regression analyses for the prediction of weighted global network efficiency from age, and for the prediction of cognitive domain scores from weighted global network efficiency. N, Number of subjects; β, standardized regression coefficient; T, T value for regression coefficient; and p, significance of the regression coefficient. For the plot of age versus FA-weighted global efficiency, we used linear regression to remove the influence of sex and years of education from the weighted global efficiency values. For the other five plots, we used the cognitive scores (including processing speed, executive, visuospatial, language, and memory) that had been adjusted for age, sex, and years of education.
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Figure 2.
The abbreviations for the nodes of the network. Each node represents a cortical region, and there are 68 nodes in each network (34 in each hemisphere). The full names of the cortical regions are listed in supplemental Table 1 (available at www.jneurosci.org as supplemental material).
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Figure 3.
Age and cognitive functions versus regional efficiency for the FA-weighted networks of the 68 cortical areas (34 in each hemisphere). Partial correlation analyses were carried out. Age, sex, and years of education were controlled for in the cognitive function versus regional efficiency analyses (including processing speed, language, executive, memory, and visuospatial). In the age versus regional efficiency analyses, sex and years of education were controlled for. To correct for multiple comparisons, we used FDR to calculate the new thresholds for p values, and 0.0320, 0.0363, 0.0190, and 0.0025 were used for the multiple comparisons for age, processing speed, and visuospatial and executive functions, respectively. The colors of the nodes refer to: red, significant after FDR correction for multiple comparisons; green, p < 0.05, significant before FDR correction; blue, p ≥ 0.05, not significant.