Article Figures & Data
Figures
- Figure 1.
A, Mean (+SEM) pre-CS and CS-elicited freezing during extinction training in Experiment 1. B, Mean (+SEM) pre-CS and CS-elicited freezing during test in Experiment 1. The asterisk (*) indicates a significant difference between groups in CS-elicited freezing. C, Cannula placements for all rats included in the final analysis of Experiment 1. •, FGF2 (n = 8); ○, Vehicle (n = 8); □, FGF2-No Ext (n = 8).
- Figure 2.
A, Mean (+SEM) pre-CS and CS-elicited freezing during extinction training in Experiment 2. B, Mean (+SEM) pre-CS and CS-elicited freezing during day 2 of extinction training in Experiment 2 for vehicle-treated rats. C, Mean (+SEM) pre-CS and CS-elicited freezing during test in Experiment 2 in Context A (“different”) and Context B (“same”). The asterisk (*) indicates a significant difference between groups in CS-elicited freezing; see text for details on significant differences in pre-CS freezing. D, Cannula placements for all rats included in the final analysis of Experiment 2. •, FGF2 (n = 7); ○, Vehicle (n = 8).
- Figure 3.
A, Mean (+SEM) pre-CS and CS-elicited freezing during extinction training in Experiment 3. B, Mean (+SEM) pre-CS and CS-elicited freezing during day 2 of extinction training in Experiment 3 for vehicle-treated rats. C, Mean (+SEM) pre-CS and CS-elicited freezing during test in Experiment 3. The asterisk (*) indicates a significant difference between groups in CS-elicited freezing; see text for details on significant differences in pre-CS freezing. D, Cannula placements for all rats included in the final analysis of Experiment 3. •, FGF2 Reinstate (n = 6); ○, Vehicle No Reinstate (n = 7); □, Vehicle Reinstate (n = 7).
Tables
Experiment/group Day 1 Day 2 Day 3 Day 4 Day 5 Experiment 1 Conditioning Extinction Test Vehicle 5 CS+ 6 CS− → Vehicle CS− — — FGF2 5 CS+ 6 CS− → FGF2 CS− — — FGF2 No Extinction 5 CS+ — → FGF2 CS− — — Experiment 2 Conditioning Extinction day 1 Extinction day 2 Test Vehicle 5 CS+ 12 CS− → Vehicle 12 CS− CS− Context A/B — FGF2 5 CS+ 6 CS− → FGF2 — CS− Context A/B — Experiment 3 Conditioning Extinction day 1 Extinction day 2 Reinstatement Test Vehicle Reinstate 5 CS+ 12 CS− → Vehicle 12 CS− Unsignaled US CS− FGF2 Reinstate 5 CS+ 6 CS− → FGF2 — Unsignaled US CS− Vehicle No Reinstate 5 CS+ 12 CS− → Vehicle 12 CS− — CS−
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