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Articles, Neurobiology of Disease

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

Jenna C. Carroll, Michiyo Iba, Debra A. Bangasser, Rita J. Valentino, Michael J. James, Kurt R. Brunden, Virginia M.-Y. Lee and John Q. Trojanowski
Journal of Neuroscience 5 October 2011, 31 (40) 14436-14449; DOI: https://doi.org/10.1523/JNEUROSCI.3836-11.2011
Jenna C. Carroll
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Michiyo Iba
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Debra A. Bangasser
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Rita J. Valentino
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Michael J. James
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Kurt R. Brunden
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Virginia M.-Y. Lee
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John Q. Trojanowski
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3836-11.2011
PubMed 
21976528
Published By 
Society for Neuroscience
History 
  • Received July 27, 2011
  • Accepted August 12, 2011
  • First published October 5, 2011.
  • Version of record published October 5, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/3114436-14$15.00/0

Author Information

  1. Jenna C. Carroll1,
  2. Michiyo Iba1,
  3. Debra A. Bangasser3,
  4. Rita J. Valentino3,
  5. Michael J. James1,
  6. Kurt R. Brunden1,
  7. Virginia M.-Y. Lee1, and
  8. John Q. Trojanowski1,2
  1. 1Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, School of Medicine and
  2. 2Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and
  3. 3Department of Anesthesiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104
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Author contributions

  1. Author contributions: J.C.C., R.J.V., K.R.B., V.M.-Y.L., and J.Q.T. designed research; J.C.C. and M.J.J. performed research; M.I., D.A.B., and R.J.V. contributed unpublished reagents/analytic tools; J.C.C. and R.J.V. analyzed data; J.C.C., R.J.V., K.R.B., V.M.-Y.L., and J.Q.T. wrote the paper.

Disclosures

    • Received July 27, 2011.
    • Accepted August 12, 2011.
  • This work was supported by NIH Grants PO1 AG17586 (V.M.-Y.L.) and MH40008 (R.J.V.) and a University of Pennsylvania Comprehensive Neuroscience Center grant (R.J.V. and V.M.-Y.L.). We thank R. Vassar for the generous BACE antibody gift, T. Bale for expert advice on CORT measurements, and K. Siniakowicz for technical assistance.

  • The authors declare no conflicts of interest.

  • Correspondence should be addressed to Dr. John Q. Trojanowski, Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, Maloney 3rd Floor, Philadelphia, PA 19104. trojanow{at}mail.med.upenn.edu

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Jul 2021124636
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Total 20234216388
Total76735601381
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The Journal of Neuroscience: 31 (40)
Journal of Neuroscience
Vol. 31, Issue 40
5 Oct 2011
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Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy
Jenna C. Carroll, Michiyo Iba, Debra A. Bangasser, Rita J. Valentino, Michael J. James, Kurt R. Brunden, Virginia M.-Y. Lee, John Q. Trojanowski
Journal of Neuroscience 5 October 2011, 31 (40) 14436-14449; DOI: 10.1523/JNEUROSCI.3836-11.2011

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Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy
Jenna C. Carroll, Michiyo Iba, Debra A. Bangasser, Rita J. Valentino, Michael J. James, Kurt R. Brunden, Virginia M.-Y. Lee, John Q. Trojanowski
Journal of Neuroscience 5 October 2011, 31 (40) 14436-14449; DOI: 10.1523/JNEUROSCI.3836-11.2011
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