Articles, Neurobiology of Disease

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

G. E. Serrano, N. Lelutiu, A. Rojas, S. Cochi, R. Shaw, C. D. Makinson, D. Wang, G. A. FitzGerald and R. Dingledine
Journal of Neuroscience 19 October 2011, 31 (42) 14850-14860; https://doi.org/10.1523/JNEUROSCI.3922-11.2011

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3922-11.2011
PubMed 
22016518
Published By 
Society for Neuroscience
History 
  • Received July 31, 2011
  • Accepted August 17, 2011
  • First published October 19, 2011.
  • Version of record published October 19, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/3114850-11$15.00/0

Author Information

  1. G. E. Serrano1,
  2. N. Lelutiu1,
  3. A. Rojas1,
  4. S. Cochi1,
  5. R. Shaw1,
  6. C. D. Makinson2,
  7. D. Wang3,
  8. G. A. FitzGerald3, and
  9. R. Dingledine1
  1. 1Department of Pharmacology and
  2. 2Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
  3. 3Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
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Author contributions

  1. Author contributions: G.E.S., A.R., and R.D. designed research; G.E.S., N.L., A.R., S.C., R.S., C.D.M., and D.W. performed research; D.W. and G.A.F. contributed unpublished reagents/analytic tools; G.E.S., A.R., G.A.F., and R.D. analyzed data; G.E.S., A.R., and R.D. wrote the paper.

Disclosures

    • Received July 31, 2011.
    • Accepted August 17, 2011.

  • This work was supported by the CounterACT Program, National Institutes of Health Office of the Director, and NINDS Grant U01NS058158 (R.D.), and by NIH Grants F32-NS064695 (G.E.S.), T32-DA015040 (A.R.), and P01 HL062250 (G.F.).

  • Correspondence should be addressed to Dr. Geidy E. Serrano, Banner Sun Health Research Institute, 10515 West Santa Fe Drive, Building B, 3rd Floor, Sun City, AZ 85351. geidy.serrano{at}bannerhealth.com

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Total2792746640
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Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus
G. E. Serrano, N. Lelutiu, A. Rojas, S. Cochi, R. Shaw, C. D. Makinson, D. Wang, G. A. FitzGerald, R. Dingledine
Journal of Neuroscience 19 October 2011, 31 (42) 14850-14860; DOI: 10.1523/JNEUROSCI.3922-11.2011
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