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Symposium and Mini-SymposiumM

The Neurophysiology and Pathology of Brain Zinc

Stefano L. Sensi, Pierre Paoletti, Jae-Young Koh, Elias Aizenman, Ashley I. Bush and Michal Hershfinkel
Journal of Neuroscience 9 November 2011, 31 (45) 16076-16085; DOI: https://doi.org/10.1523/JNEUROSCI.3454-11.2011
Stefano L. Sensi
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Pierre Paoletti
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Jae-Young Koh
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Elias Aizenman
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Ashley I. Bush
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Michal Hershfinkel
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Abstract

Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.

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The Journal of Neuroscience: 31 (45)
Journal of Neuroscience
Vol. 31, Issue 45
9 Nov 2011
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The Neurophysiology and Pathology of Brain Zinc
Stefano L. Sensi, Pierre Paoletti, Jae-Young Koh, Elias Aizenman, Ashley I. Bush, Michal Hershfinkel
Journal of Neuroscience 9 November 2011, 31 (45) 16076-16085; DOI: 10.1523/JNEUROSCI.3454-11.2011

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The Neurophysiology and Pathology of Brain Zinc
Stefano L. Sensi, Pierre Paoletti, Jae-Young Koh, Elias Aizenman, Ashley I. Bush, Michal Hershfinkel
Journal of Neuroscience 9 November 2011, 31 (45) 16076-16085; DOI: 10.1523/JNEUROSCI.3454-11.2011
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