Article Figures & Data
Figures
- Figure 1.
Rodent Aβ1–42 does not reduce LTP in slices of Tau−/− mice. a, b, Hippocampal Schaffer collateral-CA1 LTP in wild-type (a) and Tau−/− mice (b) in control ACSF (black) or after incubation with rAβ1–42 (red). The insets show superimposed example traces before and 40 min after high-frequency stimulation for each condition. Scale bars: 5 ms, 200 μV. c, Summary of results 40–45 min after high-frequency stimulation. Error bars are SEM; *p < 0.05. The numbers of slices are shown in parentheses.
- Figure 2.
Human Aβ1–42 does not reduce LTP in slices of Tau−/− mice. a, b, Hippocampal Schaffer collateral-CA1 LTP in wild-type (a) and Tau−/− mice (b) in control ACSF (black), or after incubation with hAβ1–42 (red) or the control peptide hAβ42–1 (gray). The insets show superimposed example traces before and 40 min after high-frequency stimulation for each condition. Scale bars: 5 ms, 200 μV. c, Summary of results 40–45 min after high-frequency stimulation. Error bars are SEM; **p < 0.01. The numbers of slices are shown in parentheses.
- Figure 3.
A specific inhibitor of GSK-3 reduces Aβ1–42-induced phosphorylation of tau. a, Example Western blot showing immunoreactivity to Tau5 (total Tau) and AT8 (phosphorylated Tau). b, Pooled data for AT8/Tau5 ratios normalized to immunoreactivity observed in control conditions in each mouse; *p < 0.05; **p < 0.01. The numbers of mice are shown in parentheses.
- Figure 4.
The specific GSK-3 inhibitor AR-A014418 prevents impairment of LTP by human Aβ1–42 in wild-type slices. a, Hippocampal Schaffer collateral-CA1 LTP in wild-type mice in control ACSF (black) or after incubation with AR-A014418 alone (gray) or AR-A014418 followed by incubation with hAβ1–42 (blue). The insets show superimposed example traces before and 35 min after high-frequency stimulation for each condition. Scale bars: 5 ms, 200 μV. b, Summary of results 30–35 min after high-frequency stimulation. Error bars are SEM. The numbers of slices are shown in parentheses.
Additional Files
Supplemental Material
Files in this Data Supplement:
- supplemental material - Supplemental Figures
