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Brief Communications

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

Chul-Kyu Park, Zhen-Zhong Xu, Tong Liu, Ning Lü, Charles N. Serhan and Ru-Rong Ji
Journal of Neuroscience 14 December 2011, 31 (50) 18433-18438; https://doi.org/10.1523/JNEUROSCI.4192-11.2011
Chul-Kyu Park
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Zhen-Zhong Xu
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Tong Liu
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Ning Lü
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Charles N. Serhan
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Ru-Rong Ji
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4192-11.2011
PubMed 
22171045
Published By 
Society for Neuroscience
History 
  • Received August 14, 2011
  • Revision received October 11, 2011
  • Accepted October 31, 2011
  • First published December 14, 2011.
  • Version of record published December 14, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/3118433-06$15.00/0

Author Information

  1. Chul-Kyu Park1,
  2. Zhen-Zhong Xu1,
  3. Tong Liu1,
  4. Ning Lü1,
  5. Charles N. Serhan2, and
  6. Ru-Rong Ji1
  1. 1Sensory Plasticity Laboratory, Pain Research Center, and
  2. 2Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115
View Full Text

Author contributions

  1. Author contributions: C.-K.P., Z.-Z.X., T.L., N.L., and R.-R.J. designed research; C.-K.P., Z.-Z.X., T.L., and N.L. performed research; C.-K.P., Z.-Z.X., T.L., and N.L. analyzed data; R.-R.J. and C.N.S. wrote the paper.

Disclosures

    • Received August 14, 2011.
    • Revision received October 11, 2011.
    • Accepted October 31, 2011.
  • The work was supported in part by National Institutes of Health Grants R01-DE17794 and NS54932 to R.R.J., R01-GM38765 and P01-GM095467 to C.N.S., and R01-NS67686 to both R.R.J. and C.N.S. We thank the Resolvyx Pharmaceuticals Inc. for providing resolvins and Dr. Philip J. Vickers for helpful discussion.

  • C.N.S. is an inventor on patents (resolvins) assigned to B.W.H. and licensed to Resolvyx Pharmaceuticals. C.N.S. is a scientific founder of Resolvyx Pharmaceuticals and owns equity in the company. C.N.S.' interests were reviewed and are managed by the Brigham and Women's Hospital and Partners HealthCare in accordance with their conflict of interest policies.

  • Correspondence should be addressed to Ru-Rong Ji, Department of Anesthesiology, Brigham and Women's Hospital, 75 Francis Street, Medical Research Building, Room 502, Boston, MA 02115. rrji{at}zeus.bwh.harvard.edu

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Total 202550296112
Total74136121360
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The Journal of Neuroscience: 31 (50)
Journal of Neuroscience
Vol. 31, Issue 50
14 Dec 2011
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Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1
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Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1
Chul-Kyu Park, Zhen-Zhong Xu, Tong Liu, Ning Lü, Charles N. Serhan, Ru-Rong Ji
Journal of Neuroscience 14 December 2011, 31 (50) 18433-18438; DOI: 10.1523/JNEUROSCI.4192-11.2011

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Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1
Chul-Kyu Park, Zhen-Zhong Xu, Tong Liu, Ning Lü, Charles N. Serhan, Ru-Rong Ji
Journal of Neuroscience 14 December 2011, 31 (50) 18433-18438; DOI: 10.1523/JNEUROSCI.4192-11.2011
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