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Articles, Neurobiology of Disease

Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions

Xiomara Pedre, Fabrizio Mastronardi, Wolfgang Bruck, Gerardo López-Rodas, Tanja Kuhlmann and Patrizia Casaccia
Journal of Neuroscience 2 March 2011, 31 (9) 3435-3445; DOI: https://doi.org/10.1523/JNEUROSCI.4507-10.2011
Xiomara Pedre
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Fabrizio Mastronardi
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Wolfgang Bruck
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Gerardo López-Rodas
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Tanja Kuhlmann
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Patrizia Casaccia
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4507-10.2011
PubMed 
21368055
Published By 
Society for Neuroscience
History 
  • Received August 27, 2010
  • Revision received January 5, 2011
  • Accepted January 8, 2011
  • First published March 2, 2011.
  • Version of record published March 2, 2011.
Copyright & Usage 
Copyright © 2011 the authors 0270-6474/11/313435-11$15.00/0

Author Information

  1. Xiomara Pedre1,
  2. Fabrizio Mastronardi2,
  3. Wolfgang Bruck3,
  4. Gerardo López-Rodas1,4,
  5. Tanja Kuhlmann5,*, and
  6. Patrizia Casaccia1,*
  1. 1Department of Neuroscience and Genetics and Genomics, Mount Sinai School of Medicine, New York, New York 10029,
  2. 2Inception Research and Therapeutics, Richmond Hill, Ontario L4C 7A9, Canada,
  3. 3Department of Neuropathology, University Medical Center Göttingen, D-37075 Göttingen, Germany,
  4. 4Department of Biochemistry and Molecular Biology, University of Valencia, 46100 Burjassot, Valencia, Spain, and
  5. 5Institute of Neuropathology, University Hospital Münster, D-48149 Münster, Germany
  1. Correspondence should be addressed to either of the following: Tanja Kuhlmann, Institute of Neuropathology, University Hospital Münster, Domagkstrasse 19, D-48149 Münster, Germany, tanjakuhlmann{at}gmx.de; or Patrizia Casaccia, Department of Neuroscience Genetics and Genomics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1065, New York, NY 10029, E-mail: patrizia.casaccia{at}mssm.edu
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Author contributions

  1. ↵*T.K. and P.C. contributed equally to this work.

Disclosures

    • Received August 27, 2010.
    • Revision received January 5, 2011.
    • Accepted January 8, 2011.
  • This work was supported by National Institutes of Health (NIH) Grant 2R01NS042925-08, NIH–American Recovery and Reinvestment Act Grant 3R01NS042925-07S1, and National Multiple Sclerosis Society Grant RG-4134 (P.C.); Ministerio de Ciencia y Tecnología Grants CSD2006-00049 and PR2008-0243 (G.L.-R.); and Deutsche Forschungsgemeinschaft Grant KU 1477/5-1 (T.K.). We thank Dr. Jack Antel (Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada), the Brain and Spinal Fluid Resource Center, Veterans Affairs West Los Angeles Healthcare Center (Los Angeles, CA), and the Brain-Net Germany supported by Federal Ministry of Health Grant 01GI0505 for providing multiple sclerosis tissue and control samples.

  • Inception Research and Therapeutics has no commerical interest in the work that was conducted by F.M. at The Hospital for Sick Children in Toronto, Canada.

  • Correspondence should be addressed to either of the following: Tanja Kuhlmann, Institute of Neuropathology, University Hospital Münster, Domagkstrasse 19, D-48149 Münster, Germany, tanjakuhlmann{at}gmx.de; or Patrizia Casaccia, Department of Neuroscience Genetics and Genomics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1065, New York, NY 10029, E-mail: patrizia.casaccia{at}mssm.edu

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AbstractFullPdf
Mar 20111707168220
Apr 20111534744
May 20111156234
Jun 2011812822
Jul 2011702525
Aug 2011895122
Sep 2011683330
Oct 2011827550
Nov 2011644555
Dec 2011503033
Total 20112479564535
Jan 2012644435
Feb 2012553830
Mar 2012804730
Apr 2012643534
May 2012504233
Jun 2012382718
Jul 2012463128
Aug 2012383023
Sep 2012362430
Oct 2012642528
Nov 201256215
Dec 2012592716
Total 2012650391310
Jan 2013513217
Feb 2013533128
Mar 2013462420
Apr 2013453218
May 2013352116
Jun 2013382318
Jul 201331175
Aug 201319217
Sep 2013381617
Oct 2013231213
Nov 2013412310
Dec 2013291114
Total 2013449263183
Jan 2014462211
Feb 2014381624
Mar 2014422121
Apr 2014292419
May 2014233111
Jun 2014291711
Jul 2014211312
Aug 201413109
Sep 2014202014
Oct 201439177
Nov 201428128
Dec 201431146
Total 2014359217153
Jan 2015312111
Feb 20152784
Mar 2015285715
Apr 2015192312
May 20152925
Jun 2015163315
Jul 201516117
Aug 20152464
Sep 201540610
Oct 20151973
Nov 201548188
Dec 201523109
Total 2015320202103
Jan 2016511313
Feb 201638155
Mar 2016171513
Apr 20161586
May 20162385
Jun 20161582
Jul 201616116
Aug 201619154
Sep 201621139
Oct 2016251212
Nov 201661914
Dec 2016873
Total 201625414492
Jan 201752414
Feb 201772111
Mar 201771310
Apr 201743214
May 20178478
Jun 20170198
Jul 20174152
Aug 20173207
Sep 20171143
Oct 20179174
Nov 20171348
Dec 20174146
Total 20175327095
Jan 20184246
Feb 20185195
Mar 20186184
Apr 20187132
May 20182251
Jun 20186253
Jul 20181182
Aug 20180111
Sep 20189237
Oct 20184291
Nov 20184134
Dec 20183151
Total 20185123337
Jan 20192111
Feb 20192224
Mar 20194259
Apr 20193239
May 20194264
Jun 201934011
Jul 201912211
Aug 20195178
Sep 201931911
Oct 20193146
Nov 201933518
Dec 20194213
Total 20193727595
Jan 202042012
Feb 20201111
Mar 202051111
Apr 202052110
May 2020112111
Jun 20203209
Jul 202023320
Aug 202031710
Sep 20202338
Oct 202053311
Nov 202043814
Dec 20205205
Total 202050278122
Jan 202161616
Feb 20213238
Mar 202173017
Apr 202153010
May 20211275
Jun 20214258
Jul 20212149
Aug 20212209
Sep 202132213
Oct 202142432
Nov 202141622
Dec 20211257
Total 202142272156
Jan 20221185
Feb 2022103211
Mar 20224307
Apr 202210177
May 20223216
Total 20222811836
Total477232271917
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The Journal of Neuroscience: 31 (9)
Journal of Neuroscience
Vol. 31, Issue 9
2 Mar 2011
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Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions
Xiomara Pedre, Fabrizio Mastronardi, Wolfgang Bruck, Gerardo López-Rodas, Tanja Kuhlmann, Patrizia Casaccia
Journal of Neuroscience 2 March 2011, 31 (9) 3435-3445; DOI: 10.1523/JNEUROSCI.4507-10.2011

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Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions
Xiomara Pedre, Fabrizio Mastronardi, Wolfgang Bruck, Gerardo López-Rodas, Tanja Kuhlmann, Patrizia Casaccia
Journal of Neuroscience 2 March 2011, 31 (9) 3435-3445; DOI: 10.1523/JNEUROSCI.4507-10.2011
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