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Featured ArticleArticles, Neurobiology of Disease

Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication

Yi Shen, A. Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman, Richard W. Olsen and Jing Liang
Journal of Neuroscience 4 January 2012, 32 (1) 390-401; https://doi.org/10.1523/JNEUROSCI.4639-11.2012
Yi Shen
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A. Kerstin Lindemeyer
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Claudia Gonzalez
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Xuesi M. Shao
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Igor Spigelman
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Richard W. Olsen
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Jing Liang
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4639-11.2012
PubMed 
22219299
Published By 
Society for Neuroscience
History 
  • Received September 6, 2011
  • Revision received November 6, 2011
  • Accepted November 9, 2011
  • First published January 4, 2012.
  • Version of record published January 4, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/320390-12$15.00/0

Author Information

  1. Yi Shen1,
  2. A. Kerstin Lindemeyer1,
  3. Claudia Gonzalez1,
  4. Xuesi M. Shao2,
  5. Igor Spigelman3,
  6. Richard W. Olsen1, and
  7. Jing Liang1
  1. 1Departments of Molecular and Medical Pharmacology and
  2. 2Neurobiology, David Geffen School of Medicine, and
  3. 3Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, California 90095
View Full Text

Author contributions

  1. Author contributions: X.M.S., I.S., R.W.O., and J.L. designed research; Y.S., A.K.L., C.G., and J.L. performed research; Y.S., A.K.L., C.G., X.M.S., and J.L. analyzed data; Y.S., X.M.S., I.S., R.W.O., and J.L. wrote the paper.

Disclosures

    • Received September 6, 2011.
    • Revision received November 6, 2011.
    • Accepted November 9, 2011.
  • This work was supported by United States Public Health Service Grants AA017991 (J.L.), AA07680 (R.W.O.), and AA016100 (I.S.), and Tobacco-Related Disease Research Program (California) Grant 18XT-0183 (X.M.S.). We thank Dr. Werner Sieghart for providing antibodies, Delia Tio for plasma [EtOH] assays, and Drs. Tom Otis, Jiang-hong Ye, and Martin Wallner for helpful discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jing Liang, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095. jliang{at}ucla.edu

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Total5071199305249
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The Journal of Neuroscience: 32 (1)
Journal of Neuroscience
Vol. 32, Issue 1
4 Jan 2012
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Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication
Yi Shen, A. Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman, Richard W. Olsen, Jing Liang
Journal of Neuroscience 4 January 2012, 32 (1) 390-401; DOI: 10.1523/JNEUROSCI.4639-11.2012

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Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication
Yi Shen, A. Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman, Richard W. Olsen, Jing Liang
Journal of Neuroscience 4 January 2012, 32 (1) 390-401; DOI: 10.1523/JNEUROSCI.4639-11.2012
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  • medical Benefits
    Katherine Boucher
    Published on: 13 January 2012
  • Possible Mechanism
    W. R. Klemm
    Published on: 13 January 2012
  • Published on: (13 January 2012)
    Page navigation anchor for medical Benefits
    medical Benefits
    • Katherine Boucher, retired

    I would forsee that the first most valuable utilization of this would be in tne medical care of the alcholic who presented for emergency medical treatment. Persons who require emergency surgery, for medical or trauma may encounter life threatening complications if they are undiagnosed alcoholics. In the case of the diagnosed alcholic, precautions can be taken to try to limit the impact of DTs. However, often there is a...

    Show More

    I would forsee that the first most valuable utilization of this would be in tne medical care of the alcholic who presented for emergency medical treatment. Persons who require emergency surgery, for medical or trauma may encounter life threatening complications if they are undiagnosed alcoholics. In the case of the diagnosed alcholic, precautions can be taken to try to limit the impact of DTs. However, often there is a lack of knowledge of the extent of a person's alcholal involvment. patients may have denied, or famlies may have denied. To have a tool to quickly interveen in the onset of alcholol related symptoms for such a patient could be a life saver

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
  • Published on: (13 January 2012)
    Page navigation anchor for Possible Mechanism
    Possible Mechanism
    • W. R. Klemm, Professor

    Some years back my lab published research suggesting that alcohol dehydrates membranes by displacing hydrogen-bonded water in lipid membrane domains in or near particular receptor proteins (Klemm, 1990). The mechanism for dihydromyricetin might be to reduce this membrane dehydration, either by competitive binding to hydrogen-bonding sites on membrane lipid or by sequestering alcohol molecules and reducing the population of alco...

    Show More

    Some years back my lab published research suggesting that alcohol dehydrates membranes by displacing hydrogen-bonded water in lipid membrane domains in or near particular receptor proteins (Klemm, 1990). The mechanism for dihydromyricetin might be to reduce this membrane dehydration, either by competitive binding to hydrogen-bonding sites on membrane lipid or by sequestering alcohol molecules and reducing the population of alcohol molecules available for action on such binding sites.

    Reference

    Klemm WR. Dehydration: a new alcohol theory. Alcohol. 1990 Jan-Feb;7(1):49-59.

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.

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