Cover legend: Cultured rat hippocampal neurons (21 days in vitro) that were incubated with amyloid-β oligomers for 1 h and then stained for tubulin (red) and amyloid-β (cyan). Amyloid-β oligomers bind to neurons, inducing rapid disassembly of synapses through the expression of Dickkopf-1, a Wnt antagonist. For more information, see the article by Purro et al. in this issue (pages 3492–3498).