Article Information
- Received September 27, 2011
- Revision received December 19, 2011
- Accepted January 9, 2012
- First published March 14, 2012.
- Version of record published March 14, 2012.
Author Information
- Bin Zhang1,
- Jenna Carroll1,
- John Q. Trojanowski1,
- Yuemang Yao1,
- Michiyo Iba1,
- Justin S. Potuzak2,
- Anne-Marie L. Hogan2,
- Sharon X. Xie3,
- Carlo Ballatore1,2,
- Amos B. Smith III2,
- Virginia M.-Y. Lee1, and
- Kurt R. Brunden1
- 1Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, Perelman School of Medicine,
- 2Department of Chemistry, School of Arts and Sciences, and
- 3Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Author contributions
Author contributions: B.Z., J.C., C.B., A.B.S., and K.R.B. designed research; B.Z., J.C., Y.Y., M.I., J.S.P., A.-M.L.H., and C.B. performed research; B.Z., J.C., J.Q.T., S.X.X., V.M.-Y.L., and K.R.B. analyzed data; K.R.B. wrote the paper.
Disclosures
- Received September 27, 2011.
- Revision received December 19, 2011.
- Accepted January 9, 2012.
These studies were supported by National Institutes of Health Grant U01AG029213, and in part by the Marian S. Ware Alzheimer Program, the Karen Cohen Segal and Christopher S. Segal Alzheimer Drug Discovery Initiative Fund, the Paula C. Schmerler Fund for Alzheimer's Research, the Barrist Neurodegenerative Disease Research Fund, the Eleanor Margaret Kurtz Endowed Fund, the Mary Rasmus Endowed Fund for Alzheimer's Research, Gloria J. Miller, and Dr. Arthur Peck. We thank Biao Zuo of the Biomedical Imaging Core Facility of the University of Pennsylvania for his assistance. We appreciate Nabil Darwich's assistance in quantitative EM studies. Drs. Brunden, Lee, and Trojanowski collaborate with Bristol-Myers Squibb, which has certain intellectual property rights to epothilone D, on unrelated research studies.
- Correspondence should be addressed to Dr. Kurt R. Brunden, Director of Drug Discovery, Center for Neurodegenerative Disease Research, 3600 Spruce Street, Maloney 3, Philadelphia, PA 19104. kbrunden{at}upenn.edu
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