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Articles, Cellular/Molecular

N-Glycosylation of Acid-Sensing Ion Channel 1a Regulates Its Trafficking and Acidosis-Induced Spine Remodeling

Lan Jing, Xiang-Ping Chu, Yu-Qing Jiang, Daniel M. Collier, Bin Wang, Qian Jiang, Peter M. Snyder and Xiang-Ming Zha
Journal of Neuroscience 21 March 2012, 32 (12) 4080-4091; DOI: https://doi.org/10.1523/JNEUROSCI.5021-11.2012
Lan Jing
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Xiang-Ping Chu
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Yu-Qing Jiang
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Daniel M. Collier
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Bin Wang
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Qian Jiang
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Peter M. Snyder
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Xiang-Ming Zha
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5021-11.2012
PubMed 
22442073
Published By 
Society for Neuroscience
History 
  • Received October 3, 2011
  • Revision received January 10, 2012
  • Accepted January 31, 2012
  • First published March 21, 2012.
  • Version of record published March 21, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/324080-12$15.00/0

Author Information

  1. Lan Jing1,2,*,
  2. Xiang-Ping Chu3,*,
  3. Yu-Qing Jiang1,4,*,
  4. Daniel M. Collier5,
  5. Bin Wang6,
  6. Qian Jiang3,
  7. Peter M. Snyder5, and
  8. Xiang-Ming Zha1
  1. 1Department of Cell Biology and Neuroscience, University of South Alabama College of Medicine, Mobile, Alabama 36688,
  2. 2State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China,
  3. 3Departments of Basic Medical Science and Anesthesiology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri 64108,
  4. 4Department of Urology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China,
  5. 5Departments of Internal Medicine and Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, and
  6. 6Department of Mathematics and Statistics, University of South Alabama, Mobile, Alabama 36688
View Full Text

Author contributions

  1. Author contributions: L.J., X.-P.C., Y.-Q.J., P.M.S., and X.-M.Z. designed research; L.J., X.-P.C., Y.-Q.J., D.M.C., Q.J., and X.-M.Z. performed research; L.J., X.-P.C., D.M.C., B.W., P.M.S., and X.-M.Z. analyzed data; L.J., X.-P.C., P.M.S., and X.-M.Z. wrote the paper.

  2. ↵*L.J., X.-P.C. and Y.-Q.J. contributed equally to this work.

Disclosures

    • Received October 3, 2011.
    • Revision received January 10, 2012.
    • Accepted January 31, 2012.
  • This work was supported by grants from the National Institutes of Health (R21 Grant #DA031259), the American Heart Association (Grant #0735092N), and the University of Missouri Research Board (X.-P.C.); a fellowship grant from The Third Hospital of Hebei Medical University (Y.-Q.J.), National Institutes of Health Grant HL072256 (P.M.S.), and startup funds from University of South Alabama (X.-M.Z.). The Nikon A1 confocal microscope was funded by National Institutes of Health/American Recovery & Reinvestment Act Equipment Grant #S10RR027535. We thank Drs. Michael Welsh and John Wemmie for providing the ASIC1a−/− mice and the rabbit anti-ASIC1 antibody, Dr. Michel Lazdunski for the rat ASIC1a construct, and Dr. Steven Green for the Lck-GFP construct.

  • Correspondence should be addressed to Xiang-Ming Zha, Department of Cell Biology and Neuroscience, University of South Alabama College of Medicine, 307 University Boulevard, MSB1201, Mobile, AL 36688. zha{at}jaguar1.usouthal.edu

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Article usage: March 2012 to April 2021

AbstractFullPdf
Mar 2012217578132
Apr 20125134850
May 20121934640
Jun 20121104233
Jul 2012972216
Aug 20127598
Sep 2012671419
Oct 2012533019
Nov 2012481720
Dec 2012583020
Total 20123389336357
Jan 2013364438
Feb 2013352718
Mar 2013562034
Apr 2013412832
May 2013453531
Jun 201315814
Jul 201326239
Aug 2013222220
Sep 2013191716
Oct 2013122018
Nov 2013392521
Dec 201323149
Total 2013369283260
Jan 2014171311
Feb 201413109
Mar 201421127
Apr 201421118
May 20142945
Jun 20141618199
Jul 20141914208
Aug 20141567
Sep 20141793
Oct 2014211214
Nov 201411810
Dec 20141297
Total 2014212126488
Jan 2015282014
Feb 20151696
Mar 201518198
Apr 20155149
May 201581110
Jun 20158817
Jul 20151055
Aug 20158103
Sep 201521136
Oct 201516119
Nov 201511115
Dec 2015161310
Total 2015165144102
Jan 20161347
Feb 2016566
Mar 2016181412
Apr 2016111311
May 201612125
Jun 2016744
Jul 20161233
Aug 201618161
Sep 2016101716
Oct 201611103
Nov 20165135
Dec 20160174
Total 201612212977
Jan 20172335
Feb 20170192
Mar 20170165
Apr 20170225
May 20170357
Jun 20170242
Jul 201711284
Aug 20170152
Sep 20172139
Oct 20173194
Nov 201742811
Dec 20171163
Total 20172326859
Jan 20181152
Feb 20181164
Mar 20182201
Apr 20180313
May 20180263
Jun 20180242
Jul 20181154
Aug 20180145
Sep 20183325
Oct 20181234
Nov 20181220
Dec 20180121
Total 20181025034
Jan 2019241
Feb 201921412
Mar 2019383
Apr 2019486
May 20195113
Jun 2019043
Jul 2019267
Aug 201921811
Sep 20190232
Oct 20197637
Nov 201951112
Dec 2019256
Total 20193417573
Jan 20200146
Feb 2020136
Mar 2020495
Apr 2020498
May 20202113
Jun 2020457
Jul 2020185
Aug 2020136
Sep 2020595
Oct 202032412
Nov 20201176
Dec 20203216
Total 20202913375
Jan 202122515
Feb 20210209
Mar 202112521
Apr 20211100
Total 202148045
Total435719241570
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The Journal of Neuroscience: 32 (12)
Journal of Neuroscience
Vol. 32, Issue 12
21 Mar 2012
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N-Glycosylation of Acid-Sensing Ion Channel 1a Regulates Its Trafficking and Acidosis-Induced Spine Remodeling
Lan Jing, Xiang-Ping Chu, Yu-Qing Jiang, Daniel M. Collier, Bin Wang, Qian Jiang, Peter M. Snyder, Xiang-Ming Zha
Journal of Neuroscience 21 March 2012, 32 (12) 4080-4091; DOI: 10.1523/JNEUROSCI.5021-11.2012

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N-Glycosylation of Acid-Sensing Ion Channel 1a Regulates Its Trafficking and Acidosis-Induced Spine Remodeling
Lan Jing, Xiang-Ping Chu, Yu-Qing Jiang, Daniel M. Collier, Bin Wang, Qian Jiang, Peter M. Snyder, Xiang-Ming Zha
Journal of Neuroscience 21 March 2012, 32 (12) 4080-4091; DOI: 10.1523/JNEUROSCI.5021-11.2012
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