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Brief Communications

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity

Marija Usenovic, Emilie Tresse, Joseph R. Mazzulli, J. Paul Taylor and Dimitri Krainc
Journal of Neuroscience 21 March 2012, 32 (12) 4240-4246; DOI: https://doi.org/10.1523/JNEUROSCI.5575-11.2012
Marija Usenovic
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Emilie Tresse
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Joseph R. Mazzulli
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J. Paul Taylor
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Dimitri Krainc
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5575-11.2012
PubMed 
22442086
Published By 
Society for Neuroscience
History 
  • Received November 4, 2011
  • Revision received January 24, 2012
  • Accepted February 13, 2012
  • First published March 21, 2012.
  • Version of record published March 21, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/324240-07$15.00/0

Author Information

  1. Marija Usenovic1,2,
  2. Emilie Tresse3,
  3. Joseph R. Mazzulli1,
  4. J. Paul Taylor3, and
  5. Dimitri Krainc1
  1. 1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MassGeneral Institute for Neurodegenerative Disease, Charlestown, Massachusetts 02129,
  2. 2Mediterranean Institute for Life Sciences, Split 2100, Croatia, and
  3. 3Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
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Author contributions

  1. Author contributions: M.U. and D.K. designed research; M.U., E.T., and J.R.M. performed research; M.U., E.T., J.R.M., J.P.T., and D.K. analyzed data; M.U. and D.K. wrote the paper.

Disclosures

    • Received November 4, 2011.
    • Revision received January 24, 2012.
    • Accepted February 13, 2012.
  • This work was supported by NIH Grant R01NS051303 (to D.K.). J.P.T. and E.T. were supported by NIH Grant R01AG031587. We thank Drs. Christine Klein for patient fibroblasts, Carolyn M. Sue for ATP13A2-GFP construct, Thomas J. Diefenbach for assistance with confocal microscopy, and Isabella Palazzolo, Hyunkyung Jeong, and other members of Krainc laboratory for helpful suggestions and discussions.

  • Correspondence should be addressed to Dr. Dimitri Krainc, MassGeneral Institute for Neurodegenerative Disease, 114 16th Street, Room 2008, Charlestown, MA 02129. krainc{at}helix.mgh.harvard.edu

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The Journal of Neuroscience: 32 (12)
Journal of Neuroscience
Vol. 32, Issue 12
21 Mar 2012
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Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
Marija Usenovic, Emilie Tresse, Joseph R. Mazzulli, J. Paul Taylor, Dimitri Krainc
Journal of Neuroscience 21 March 2012, 32 (12) 4240-4246; DOI: 10.1523/JNEUROSCI.5575-11.2012

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Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
Marija Usenovic, Emilie Tresse, Joseph R. Mazzulli, J. Paul Taylor, Dimitri Krainc
Journal of Neuroscience 21 March 2012, 32 (12) 4240-4246; DOI: 10.1523/JNEUROSCI.5575-11.2012
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