Figure 1. Aβ plaque deposition is associated with decreased functional connectivity in multiple brain systems of older APP/PS1 mice. A–F, Composite, group-averaged, functional correlation maps of frontal (FC, A), motor (MC, B), somatosensory (SC, C), cingulate (CC, D), retrosplenial (RC, E) and visual (VC, F) cortices in young and older APP/PS1 mice. Black circles denote seed position. G, Regional bilateral functional correlation in young (black bars) and older (white bars) APP/PS1 mice (n = 7/group). *p < 0.05, ***p < 0.001. Values represent mean ± SEM. H, Locations of cortical functional regions, anatomical landmarks (white circles), and seed placement and size (black circles) were manually constructed (White et al., 2011) using the Franklin and Paxinos (1996) histological atlas.