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Brief Communications

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

Jun Wang, Mario G. Ferruzzi, Lap Ho, Jack Blount, Elsa M. Janle, Bing Gong, Yong Pan, G. A. Nagana Gowda, Daniel Raftery, Isabel Arrieta-Cruz, Vaishali Sharma, Bruce Cooper, Jessica Lobo, James E. Simon, Chungfen Zhang, Alice Cheng, Xianjuan Qian, Kenjiro Ono, David B. Teplow, Constantine Pavlides, Richard A. Dixon and Giulio M. Pasinetti
Journal of Neuroscience 11 April 2012, 32 (15) 5144-5150; https://doi.org/10.1523/JNEUROSCI.6437-11.2012
Jun Wang
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Mario G. Ferruzzi
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Lap Ho
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Jack Blount
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Elsa M. Janle
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Bing Gong
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Yong Pan
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G. A. Nagana Gowda
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Daniel Raftery
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Isabel Arrieta-Cruz
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Vaishali Sharma
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Bruce Cooper
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Jessica Lobo
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James E. Simon
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Chungfen Zhang
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Alice Cheng
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Xianjuan Qian
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Kenjiro Ono
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David B. Teplow
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Constantine Pavlides
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Richard A. Dixon
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Giulio M. Pasinetti
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.6437-11.2012
PubMed 
22496560
Published By 
Society for Neuroscience
History 
  • Received December 23, 2011
  • Revision received February 24, 2012
  • Accepted February 27, 2012
  • First published April 11, 2012.
  • Version of record published April 11, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/325144-07$15.00/0

Author Information

  1. Jun Wang1,9,
  2. Mario G. Ferruzzi3,
  3. Lap Ho1,9,
  4. Jack Blount5,
  5. Elsa M. Janle3,
  6. Bing Gong1,
  7. Yong Pan1,
  8. G. A. Nagana Gowda4,
  9. Daniel Raftery4,
  10. Isabel Arrieta-Cruz1,
  11. Vaishali Sharma5,
  12. Bruce Cooper3,
  13. Jessica Lobo3,
  14. James E. Simon7,
  15. Chungfen Zhang5,
  16. Alice Cheng1,
  17. Xianjuan Qian1,
  18. Kenjiro Ono8,
  19. David B. Teplow8,
  20. Constantine Pavlides6,
  21. Richard A. Dixon5, and
  22. Giulio M. Pasinetti1,2,9
  1. 1Department of Neurology and
  2. 2Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029,
  3. 3Departments of Food Science and Foods and Nutrition and
  4. 4Department of Chemistry, Purdue University, West Lafayette, Indiana 47907,
  5. 5Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401,
  6. 6The Rockefeller University, New York, New York 10021,
  7. 7Department of Plant Biology and Plant Pathology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey 08901,
  8. 8Department of Neurology, David Geffen School of Medicine, and Brain Research Institute, and Molecular Biology Institute, University of California, Los Angeles, California 90095, and
  9. 9Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York 10468
View Full Text

Author contributions

  1. Author contributions: J.W., M.G.F., L.H., E.M.J., D.R., J.E.S., D.B.T., C.P., R.A.D., and G.M.P. designed research; J.W., J.B., E.M.J., B.G., Y.P., G.A.N.G., I.A.-C., V.S., B.C., J.L., C.Z., A.C., X.Q., and K.O. performed research; J.W., M.G.F., E.M.J., B.G., G.A.N.G., D.R., J.E.S., D.B.T., C.P., R.A.D., and G.M.P. analyzed data; J.W., M.G.F., L.H., and G.M.P. wrote the paper.

Disclosures

    • Received December 23, 2011.
    • Revision received February 24, 2012.
    • Accepted February 27, 2012.
  • This work was supported by grants from the NIH (PO1AT004511) and Department of Veterans Affairs to G.M.P., the Jim Easton Consortium for Alzheimer's Drug Discovery and Biomarkers at University of California Los Angeles to D.B.T., NIH Grant AG027818 to D.B.T., and the Samuel Roberts Noble Foundation (R.A.D.).

  • Correspondence should be addressed to Dr. Giulio M. Pasinetti, Department of Neurology, The Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1137, New York, NY 10029. giulio.pasinetti{at}mssm.edu

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Feb 202132718
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Apr 2021173517
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Jul 202575410
Aug 2025113417
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Total 2025142476155
Total153134721586
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The Journal of Neuroscience: 32 (15)
Journal of Neuroscience
Vol. 32, Issue 15
11 Apr 2012
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Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment
Jun Wang, Mario G. Ferruzzi, Lap Ho, Jack Blount, Elsa M. Janle, Bing Gong, Yong Pan, G. A. Nagana Gowda, Daniel Raftery, Isabel Arrieta-Cruz, Vaishali Sharma, Bruce Cooper, Jessica Lobo, James E. Simon, Chungfen Zhang, Alice Cheng, Xianjuan Qian, Kenjiro Ono, David B. Teplow, Constantine Pavlides, Richard A. Dixon, Giulio M. Pasinetti
Journal of Neuroscience 11 April 2012, 32 (15) 5144-5150; DOI: 10.1523/JNEUROSCI.6437-11.2012

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Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment
Jun Wang, Mario G. Ferruzzi, Lap Ho, Jack Blount, Elsa M. Janle, Bing Gong, Yong Pan, G. A. Nagana Gowda, Daniel Raftery, Isabel Arrieta-Cruz, Vaishali Sharma, Bruce Cooper, Jessica Lobo, James E. Simon, Chungfen Zhang, Alice Cheng, Xianjuan Qian, Kenjiro Ono, David B. Teplow, Constantine Pavlides, Richard A. Dixon, Giulio M. Pasinetti
Journal of Neuroscience 11 April 2012, 32 (15) 5144-5150; DOI: 10.1523/JNEUROSCI.6437-11.2012
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