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Articles, Cellular/Molecular

Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo

Michael C. Kelly, Qing Chang, Alex Pan, Xi Lin and Ping Chen
Journal of Neuroscience 9 May 2012, 32 (19) 6699-6710; DOI: https://doi.org/10.1523/JNEUROSCI.5420-11.2012
Michael C. Kelly
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Qing Chang
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Alex Pan
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Xi Lin
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Ping Chen
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5420-11.2012
PubMed 
22573692
Published By 
Society for Neuroscience
History 
  • Received October 26, 2011
  • Revision received February 21, 2012
  • Accepted March 21, 2012
  • First published May 9, 2012.
  • Version of record published May 9, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/326699-12$15.00/0

Author Information

  1. Michael C. Kelly1,
  2. Qing Chang2,
  3. Alex Pan1,
  4. Xi Lin1,2, and
  5. Ping Chen1,2
  1. 1Departments of Cell Biology and
  2. 2Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322
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Author contributions

  1. Author contributions: M.C.K., Q.C., X.L., and P.C. designed research; M.C.K., Q.C., and A.P. performed research; M.C.K., X.L., and P.C. contributed unpublished reagents/analytic tools; M.C.K., Q.C., A.P., X.L., and P.C. analyzed data; M.C.K., Q.C., and P.C. wrote the paper.

Disclosures

    • Received October 26, 2011.
    • Revision received February 21, 2012.
    • Accepted March 21, 2012.
  • This work was supported by National Institutes of Health (NIH)–National Institute on Deafness and Other Communication Disorders Grant R01 DC05213 and in part by the National Basic Research Program of China (973 Program) Grant 2012CB967902 and Natural Science Foundation of China Grant 81028003/H1305 (P.C.), and NIH–National Institute of General Medical Sciences Training Grant 5T32GM008605-12 (M.K.). The study was supported in part by the Neuronal Imaging Core of the Emory Neuroscience National Institute of Neurological Disorders and Stroke Core Facilities grant (P30NS055077). The Emory transgenic core staff assisted with generation of the TgAtoh1 mouse line. We thank the members of the Chen laboratory for helpful discussion, Dr. Yibo Huang for assistance with some of the experiments, Dr. Amy Kiernan for advice on doxycycline administration, Dr. James Bartle for the Espin antibody, and Dr. Jian Zuo and Dr. Zhiyong Liu for critical review of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Ping Chen, Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, GA 30322. ping.chen{at}emory.edu

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May 20122337170292
Jun 20122146850
Jul 20121625166
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Apr 2013804442
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Jul 2013351818
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Feb 2014181524
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Jul 2014242517
Aug 2014122025
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Oct 2014181410
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Total 2014323210207
Jan 2015371712
Feb 2015245735
Mar 2015241410
Apr 201518188
May 2015192514
Jun 2015121610
Jul 201513820
Aug 20151379
Sep 2015181919
Oct 2015481211
Nov 201519911
Dec 2015291316
Total 2015274215175
Jan 2016231611
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Apr 201627919
May 2016262115
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Jul 2016451625
Aug 201635145
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Oct 2016251114
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Total 2016336206186
Jan 20172294
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Mar 201726028
Apr 201713920
May 20177469
Jun 20172255
Jul 20173218
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Sep 201732713
Oct 20172313
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Total 201730413129
Jan 20181288
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Aug 20181432
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Feb 201975418
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Apr 20197178
May 201992110
Jun 2019131617
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Aug 2019138312
Sep 2019101393
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Nov 2019102613
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Total 2019128665131
Jan 202019279
Feb 2020122519
Mar 2020172115
Apr 202013158
May 2020152319
Jun 2020121811
Jul 202011104
Aug 2020191010
Sep 2020212412
Oct 2020182914
Nov 202017348
Dec 202014306
Total 2020188266135
Jan 2021104222
Feb 2021122920
Mar 2021183621
Apr 2021112019
May 2021164417
Jun 2021104315
Jul 202183415
Aug 202163011
Sep 202119319
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Total 2021136416217
Jan 202272916
Feb 20224216
Mar 202253015
Apr 202283416
May 202262918
Total 20223014371
Total517338202332
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The Journal of Neuroscience: 32 (19)
Journal of Neuroscience
Vol. 32, Issue 19
9 May 2012
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Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo
Michael C. Kelly, Qing Chang, Alex Pan, Xi Lin, Ping Chen
Journal of Neuroscience 9 May 2012, 32 (19) 6699-6710; DOI: 10.1523/JNEUROSCI.5420-11.2012

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Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo
Michael C. Kelly, Qing Chang, Alex Pan, Xi Lin, Ping Chen
Journal of Neuroscience 9 May 2012, 32 (19) 6699-6710; DOI: 10.1523/JNEUROSCI.5420-11.2012
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