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Articles, Development/Plasticity/Repair

Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain

Michael V. Lombardo, Emma Ashwin, Bonnie Auyeung, Bhismadev Chakrabarti, Kevin Taylor, Gerald Hackett, Edward T. Bullmore and Simon Baron-Cohen
Journal of Neuroscience 11 January 2012, 32 (2) 674-680; DOI: https://doi.org/10.1523/JNEUROSCI.4389-11.2012
Michael V. Lombardo
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Emma Ashwin
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Bonnie Auyeung
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Bhismadev Chakrabarti
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Kevin Taylor
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Gerald Hackett
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Edward T. Bullmore
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Simon Baron-Cohen
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4389-11.2012
PubMed 
22238103
Published By 
Society for Neuroscience
History 
  • Received August 26, 2011
  • Revision received October 24, 2011
  • Accepted November 1, 2011
  • First published January 11, 2012.
  • Version of record published January 11, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/320674-07$15.00/0 This article is freely available online through the J Neurosci Open Choice option.

Author Information

  1. Michael V. Lombardo1,
  2. Emma Ashwin1,2,
  3. Bonnie Auyeung1,
  4. Bhismadev Chakrabarti1,3,
  5. Kevin Taylor4,
  6. Gerald Hackett5,
  7. Edward T. Bullmore6, and
  8. Simon Baron-Cohen1
  1. 1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, United Kingdom,
  2. 2Department of Psychology, University of Bath, Bath BA2 7AY, United Kingdom,
  3. 3Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AH, United Kingdom,
  4. 4Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom,
  5. 5Department of Fetal Medicine, Rosie Maternity Hospital, Cambridge CB2 0SW, United Kingdom, and
  6. 6Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom
View Full Text

Author contributions

  1. Author contributions: E.A., G.H., and S.B.-C. designed research; E.A. and B.A. performed research; M.V.L. and K.T. contributed unpublished reagents/analytic tools; M.V.L. analyzed data; M.V.L., B.A., B.C., E.T.B., and S.B.-C. wrote the paper.

View Abstract

Disclosures

    • Received August 26, 2011.
    • Revision received October 24, 2011.
    • Accepted November 1, 2011.
  • This work was supported by grants from the Wellcome Trust and the MRC (to S.B.-C. and E.T.B.) and was conducted in association with the NIHR CLAHRC for Cambridgeshire and Peterborough Foundation National Health Services Trust. M.V.L., B.C., and B.A. were supported by Research Fellowships from Jesus, Darwin, and Wolfson Colleges, respectively. FT assays were made possible by a grant to S.B.-C. from the Nancy Lurie Marks Family Foundation. We thank John Suckling, Meng-Chuan Lai, Amber Ruigrok, and Rebecca Knickmeyer for valuable comments and discussions. We also thank the families who have taken part in this longitudinal study. Finally, we thank the NIH Pediatric MRI Data Repository created by the NIH MRI Study of Normal Brain Development. This is a multisite, longitudinal study of typically developing children, from newborns to young adults, conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke (Contract numbers N01-HD02-3343, N01-MH9-0002, and N01-NS-9-2314, -2315, -2316, -2317, -2319, and -2320). A listing of the participating sites and a complete listing of the study investigators can be found at https://nihpd.crbs.ucsd.edu/nihpd/info/participating_centers.html.

  • This manuscript reflects the views of the authors and may not reflect the opinions or views of the Brain Development Cooperative Group Investigators or the NIH.

  • E.T.B. is half-time used by the University of Cambridge and half-time by GlaxoSmithKline. The other authors declare no competing financial interests.

  • Correspondence should be addressed to either Michael V. Lombardo or Simon Baron-Cohen, Autism Research Centre, Douglas House, 18B Trumpington Road, Cambridge CB2 8AH, UK. ml437{at}cam.ac.uk or sb205{at}cam.ac.uk

Online Impact

 

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Jan 201815778
Feb 2018276714
Mar 2018439523
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May 2018258912
Jun 201820788
Jul 2018218337
Aug 2018187618
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Mar 2019268745
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Jun 2019155530
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Aug 2019257926
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Total 2019356858381
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Feb 2020196319
Mar 2020137927
May 20203310440
Jun 2020145927
Jul 2020234022
Aug 2020116515
Sep 2020565254
Oct 2020577139
Nov 2020478753
Dec 2020339248
Total 2020342782381
Jan 2021577037
Feb 2021477928
Mar 2021358240
Apr 20213211727
May 20213110226
Jun 2021218333
Jul 2021246335
Aug 2021237320
Sep 2021269026
Oct 2021185731
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Total 2021366962369
Jan 20223010527
Feb 2022239637
Mar 2022266628
Apr 20222710734
May 2022258622
Jun 2022145128
Jul 2022216612
Aug 2022196019
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Total 2022266826272
Jan 20232910436
Feb 2023105518
Mar 2023237546
Apr 2023258129
May 2023273933
Jun 202393814
Jul 2023112725
Aug 2023183718
Sep 202366611
Total 2023158522230
Total178350701876
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The Journal of Neuroscience: 32 (2)
Journal of Neuroscience
Vol. 32, Issue 2
11 Jan 2012
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Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain
Michael V. Lombardo, Emma Ashwin, Bonnie Auyeung, Bhismadev Chakrabarti, Kevin Taylor, Gerald Hackett, Edward T. Bullmore, Simon Baron-Cohen
Journal of Neuroscience 11 January 2012, 32 (2) 674-680; DOI: 10.1523/JNEUROSCI.4389-11.2012

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Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain
Michael V. Lombardo, Emma Ashwin, Bonnie Auyeung, Bhismadev Chakrabarti, Kevin Taylor, Gerald Hackett, Edward T. Bullmore, Simon Baron-Cohen
Journal of Neuroscience 11 January 2012, 32 (2) 674-680; DOI: 10.1523/JNEUROSCI.4389-11.2012
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