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Articles, Development/Plasticity/Repair

Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain

Michael V. Lombardo, Emma Ashwin, Bonnie Auyeung, Bhismadev Chakrabarti, Kevin Taylor, Gerald Hackett, Edward T. Bullmore and Simon Baron-Cohen
Journal of Neuroscience 11 January 2012, 32 (2) 674-680; DOI: https://doi.org/10.1523/JNEUROSCI.4389-11.2012
Michael V. Lombardo
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Emma Ashwin
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Bonnie Auyeung
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Bhismadev Chakrabarti
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Kevin Taylor
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Gerald Hackett
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Edward T. Bullmore
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Simon Baron-Cohen
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    Figure 1.

    FT correlations with local GM volume. A, Areas where FT predicts local gray matter volume. Red/orange voxels denote positive correlations; blue voxels denote negative correlations. B, Areas of sexual dimorphism in local GM volume. Red/orange voxels denote a Male > Female pattern; blue voxels denote a Female > Male pattern.

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    Figure 2.

    Overlap of FT–GM correlations and sexual dimorphism. A, Conjunction analysis overlap between sexual dimorphism and FT correlation in PT/PO, plOFC, and RTPJ/pSTS. Red voxels show overlap from the conjunction of FT positive correlation and Male > Female; blue voxels show overlap from the conjunction of FT negative correlation and Female > Male. B, Scatterplot showing the partial correlation between FT and GM volume within sexually dimorphic voxels in right PT/PO. Adjusted predictor and outcome values are plotted on the x and y axes. C, Scatterplot showing the partial correlation between FT and GM volume within sexually dimorphic voxels in RTPJ/pSTS. Adjusted predictor and outcome values are plotted on the x and y axes. D, Scatterplot showing the partial correlation between FT and GM volume within sexually dimorphic voxels in right plOFC. Adjusted predictor and outcome values are plotted on the x and y axes.

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    Table 1.

    Correlations between FT and local GM volume after controlling for age and total GM volume

    RegionHemisphereBAMNI (x, y, z)t valueCluster sizep value
    Positive correlation
    Postcentral gyrusL3−43, −29, 606.8382529.99 × 10−5
    Postcentral gyrusL3−45, −25, 526.83
        Precentral gyrusL44−39, 14, 405.10
        Postcentral gyrusR345, −26, 665.6872731.98 × 10−4
        Central sulcusR451, −16, 615.63
        Central sulcusR646, −9, 454.08
    RTPJR3941, −64, 324.9638980.045
        RTPJR3949, −51, 294.72
        pSTSR2261, −48, 234.36
    Amygdala*L—−18, −6, −274.460.0338*
    Negative correlation
    PT/POR4849, −20, 145.71188719.99 × 10−5
        plOFCR4826, 17, −205.69
        sgACCB251, 20, −125.43
        Pars triangularisR4551, 21, 03.77
        Anterior insulaR4732, 21, −113.72
    PT/POL22−66, −24, 157.90149489.99 × 10−5
        plOFCL38−33, 17, −205.47
        mSTSL21−63, −19, −84.95
        Pars triangularisL47−53, 31, −93.83
        Anterior insulaL47−43, 23, −33.71
    • p values are cluster-corrected based on extent.

    • ↵*p < 0.05 FWE using small-volume correction. L, Left; R, right.

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The Journal of Neuroscience: 32 (2)
Journal of Neuroscience
Vol. 32, Issue 2
11 Jan 2012
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Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain
Michael V. Lombardo, Emma Ashwin, Bonnie Auyeung, Bhismadev Chakrabarti, Kevin Taylor, Gerald Hackett, Edward T. Bullmore, Simon Baron-Cohen
Journal of Neuroscience 11 January 2012, 32 (2) 674-680; DOI: 10.1523/JNEUROSCI.4389-11.2012

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Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain
Michael V. Lombardo, Emma Ashwin, Bonnie Auyeung, Bhismadev Chakrabarti, Kevin Taylor, Gerald Hackett, Edward T. Bullmore, Simon Baron-Cohen
Journal of Neuroscience 11 January 2012, 32 (2) 674-680; DOI: 10.1523/JNEUROSCI.4389-11.2012
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