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Articles, Development/Plasticity/Repair

Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish

Yona Goldshmit, Tamar E. Sztal, Patricia R. Jusuf, Thomas E. Hall, Mai Nguyen-Chi and Peter D. Currie
Journal of Neuroscience 30 May 2012, 32 (22) 7477-7492; DOI: https://doi.org/10.1523/JNEUROSCI.0758-12.2012
Yona Goldshmit
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
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Tamar E. Sztal
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
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Patricia R. Jusuf
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
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Thomas E. Hall
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
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Mai Nguyen-Chi
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
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Peter D. Currie
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
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Abstract

Adult zebrafish show a remarkable capacity to regenerate their spinal column after injury, an ability that stands in stark contrast to the limited repair that occurs within the mammalian CNS post-injury. The reasons for this interspecies difference in regenerative capacity remain unclear. Here we demonstrate a novel role for Fgf signaling during glial cell morphogenesis in promoting axonal regeneration after spinal cord injury. Zebrafish glia are induced by Fgf signaling, to form an elongated bipolar morphology that forms a bridge between the two sides of the resected spinal cord, over which regenerating axons actively migrate. Loss of Fgf function inhibits formation of this “glial bridge” and prevents axon regeneration. Despite the poor potential for mammalian axonal regeneration, primate astrocytes activated by Fgf signaling adopt a similar morphology to that induced in zebrafish glia. This suggests that differential Fgf regulation, rather than intrinsic cell differences, underlie the distinct responses of mammalian and zebrafish glia to injury.

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The Journal of Neuroscience: 32 (22)
Journal of Neuroscience
Vol. 32, Issue 22
30 May 2012
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Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish
Yona Goldshmit, Tamar E. Sztal, Patricia R. Jusuf, Thomas E. Hall, Mai Nguyen-Chi, Peter D. Currie
Journal of Neuroscience 30 May 2012, 32 (22) 7477-7492; DOI: 10.1523/JNEUROSCI.0758-12.2012

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Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish
Yona Goldshmit, Tamar E. Sztal, Patricia R. Jusuf, Thomas E. Hall, Mai Nguyen-Chi, Peter D. Currie
Journal of Neuroscience 30 May 2012, 32 (22) 7477-7492; DOI: 10.1523/JNEUROSCI.0758-12.2012
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