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Articles, Neurobiology of Disease

Synaptic Plasticity Defect Following Visual Deprivation in Alzheimer's Disease Model Transgenic Mice

Christopher M. William, Mark L. Andermann, Glenn J. Goldey, Demetris K. Roumis, R. Clay Reid, Carla J. Shatz, Mark W. Albers, Matthew P. Frosch and Bradley T. Hyman
Journal of Neuroscience 6 June 2012, 32 (23) 8004-8011; https://doi.org/10.1523/JNEUROSCI.5369-11.2012
Christopher M. William
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Mark L. Andermann
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Glenn J. Goldey
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Demetris K. Roumis
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R. Clay Reid
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Carla J. Shatz
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Mark W. Albers
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Matthew P. Frosch
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Bradley T. Hyman
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5369-11.2012
PubMed 
22674275
Published By 
Society for Neuroscience
History 
  • Received October 24, 2011
  • Revision received April 11, 2012
  • Accepted April 23, 2012
  • First published June 6, 2012.
  • Version of record published June 6, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/328004-08$15.00/0

Author Information

  1. Christopher M. William1,2,
  2. Mark L. Andermann3,
  3. Glenn J. Goldey3,
  4. Demetris K. Roumis3,
  5. R. Clay Reid3,
  6. Carla J. Shatz4,
  7. Mark W. Albers2,
  8. Matthew P. Frosch1,2, and
  9. Bradley T. Hyman2
  1. 1Neuropathology Service,
  2. 2MassGeneral Institute for Neurodegenerative Disease, Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129,
  3. 3Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, and
  4. 4Bio-X, Stanford University, Stanford, California 94305
View Full Text

Author contributions

  1. Author contributions: C.M.W., M.L.A., R.C.R., C.J.S., M.W.A., M.P.F., and B.T.H. designed research; C.M.W., M.L.A., G.J.G., and D.K.R. performed research; C.M.W., M.L.A., G.J.G., and D.K.R. analyzed data; C.M.W., M.L.A., G.J.G., D.K.R., R.C.R., C.J.S., M.W.A., M.P.F., and B.T.H. wrote the paper.

Disclosures

    • Received October 24, 2011.
    • Revision received April 11, 2012.
    • Accepted April 23, 2012.
  • This work was supported by NIH (Grants K08 NS069811 to C.M.W., R01 EY018742 to R.C.R., DP2 OD006662 to M.W.A.), by the Dr. and Mrs. E.P. Richardson Jr. Fund for Neuropathology (C.M.W.), by a fellowship from the Ludcke Foundation and Pierce Charitable Trust (M.L.A.), and by the Mathers Charitable Foundation (C.J.S.). We thank Anthony Moffa for assistance with data collection and Sergey Yurgenson and Aleksandr Vagodny for technical contributions. We thank members of the Shatz, Hyman, and Reid laboratories for advice and discussion.

  • Correspondence should be addressed to Bradley T. Hyman, MassGeneral Institute for Neurodegenerative Disease, Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129. bhyman{at}partners.org

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Jan 20182209
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Total 20203917989
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Jan 202562712
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Apr 202513513
May 2025186
Total 20251918053
Total4152582875
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The Journal of Neuroscience: 32 (23)
Journal of Neuroscience
Vol. 32, Issue 23
6 Jun 2012
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Synaptic Plasticity Defect Following Visual Deprivation in Alzheimer's Disease Model Transgenic Mice
Christopher M. William, Mark L. Andermann, Glenn J. Goldey, Demetris K. Roumis, R. Clay Reid, Carla J. Shatz, Mark W. Albers, Matthew P. Frosch, Bradley T. Hyman
Journal of Neuroscience 6 June 2012, 32 (23) 8004-8011; DOI: 10.1523/JNEUROSCI.5369-11.2012

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Synaptic Plasticity Defect Following Visual Deprivation in Alzheimer's Disease Model Transgenic Mice
Christopher M. William, Mark L. Andermann, Glenn J. Goldey, Demetris K. Roumis, R. Clay Reid, Carla J. Shatz, Mark W. Albers, Matthew P. Frosch, Bradley T. Hyman
Journal of Neuroscience 6 June 2012, 32 (23) 8004-8011; DOI: 10.1523/JNEUROSCI.5369-11.2012
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