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Articles, Behavioral/Systems/Cognitive

Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels

Jessica S. Damoiseaux, William W. Seeley, Juan Zhou, William R. Shirer, Giovanni Coppola, Anna Karydas, Howard J. Rosen, Bruce L. Miller, Joel H. Kramer and Michael D. Greicius
Journal of Neuroscience 13 June 2012, 32 (24) 8254-8262; DOI: https://doi.org/10.1523/JNEUROSCI.0305-12.2012
Jessica S. Damoiseaux
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William W. Seeley
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Juan Zhou
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William R. Shirer
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Giovanni Coppola
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Anna Karydas
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Howard J. Rosen
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Bruce L. Miller
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Joel H. Kramer
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Michael D. Greicius
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0305-12.2012
PubMed 
22699906
Published By 
Society for Neuroscience
History 
  • Received January 20, 2012
  • Revision received April 17, 2012
  • Accepted April 18, 2012
  • First published June 13, 2012.
  • Version of record published June 13, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/308254-09$15.00/0

Author Information

  1. Jessica S. Damoiseaux1,
  2. William W. Seeley2,
  3. Juan Zhou3,
  4. William R. Shirer1,
  5. Giovanni Coppola4,
  6. Anna Karydas2,
  7. Howard J. Rosen2,
  8. Bruce L. Miller2,
  9. Joel H. Kramer2, and
  10. Michael D. Greicius1
  11. for the Alzheimer's Disease Neuroimaging Initiative
  1. 1Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305,
  2. 2Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143-1207,
  3. 3Neuroscience and Behavioral Disorders Program, Duke–National University of Singapore Graduate Medical School, Singapore 169857, and
  4. 4Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
View Full Text

Author contributions

  1. Author contributions: W.W.S., B.L.M., J.H.K., and M.D.G. designed research; W.W.S., J.Z., G.C., A.K., and J.H.K. performed research; J.Z., W.R.S., G.C., A.K., H.J.R., and B.L.M. contributed unpublished reagents/analytic tools; J.S.D. analyzed data; J.S.D. and M.D.G. wrote the paper.

Disclosures

    • Received January 20, 2012.
    • Revision received April 17, 2012.
    • Accepted April 18, 2012.
  • This work was supported by the Hillblom Foundation, the John Douglas French Alzheimer's Disease Foundation, the JNA Foundation, and National Institutes of Health Grants NS073498 and AG032306. We thank William Irwin, Maria Molfino, and Heidi Jiang for their help with MRI data transfer and preprocessing; and Eric Klein for his help with the APOE genotyping. Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI; National Institutes of Health Grant U01 AG024904). The Canadian Institutes of Health Research provides funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health. The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuroimaging at the University of California, Los Angeles. Cerebrospinal data used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (www.loni.ucla.edu/ADNI). As such, ADNI investigators contributed to the design and implementation of ADNI and/or provided data but did not participate in the analysis or writing of this report. A complete listing of ADNI investigators can be found at http://adni.loni.ucla.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either Jessica S. Damoiseaux or Michael D. Greicius, Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 780 Welch Road, Palo Alto, CA 94304. jeske{at}stanford.edu or greicius{at}stanford.edu

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Jan 20184557
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The Journal of Neuroscience: 32 (24)
Journal of Neuroscience
Vol. 32, Issue 24
13 Jun 2012
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Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels
Jessica S. Damoiseaux, William W. Seeley, Juan Zhou, William R. Shirer, Giovanni Coppola, Anna Karydas, Howard J. Rosen, Bruce L. Miller, Joel H. Kramer, Michael D. Greicius
Journal of Neuroscience 13 June 2012, 32 (24) 8254-8262; DOI: 10.1523/JNEUROSCI.0305-12.2012

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Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels
Jessica S. Damoiseaux, William W. Seeley, Juan Zhou, William R. Shirer, Giovanni Coppola, Anna Karydas, Howard J. Rosen, Bruce L. Miller, Joel H. Kramer, Michael D. Greicius
Journal of Neuroscience 13 June 2012, 32 (24) 8254-8262; DOI: 10.1523/JNEUROSCI.0305-12.2012
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