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Brief Communications

Differing Semaphorin 3A Concentrations Trigger Distinct Signaling Mechanisms in Growth Cone Collapse

Richard P. C. Manns, Geoffrey M. W. Cook, Christine E. Holt and Roger J. Keynes
Journal of Neuroscience 20 June 2012, 32 (25) 8554-8559; https://doi.org/10.1523/JNEUROSCI.5964-11.2012
Richard P. C. Manns
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Geoffrey M. W. Cook
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Christine E. Holt
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Roger J. Keynes
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5964-11.2012
PubMed 
22723695
Published By 
Society for Neuroscience
History 
  • Received November 30, 2011
  • Revision received April 27, 2012
  • Accepted May 5, 2012
  • First published June 20, 2012.
  • Version of record published June 20, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/328554-06$15.00/0 This article is freely available online through the J Neurosci Open Choice option.

Author Information

  1. Richard P. C. Manns,
  2. Geoffrey M. W. Cook,
  3. Christine E. Holt, and
  4. Roger J. Keynes
  1. Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
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Author contributions

  1. Author contributions: R.P.C.M., G.M.W.C., C.E.H., and R.J.K. designed research; R.P.C.M., G.M.W.C., and R.J.K. performed research; R.P.C.M., G.M.W.C., C.E.H., and R.J.K. analyzed data; R.P.C.M., G.M.W.C., C.E.H., and R.J.K. wrote the paper.

Disclosures

    • Received November 30, 2011.
    • Revision received April 27, 2012.
    • Accepted May 5, 2012.
  • This work was funded by a project grant from the Wellcome Trust and a graduate studentship to R.P.C.M. from Trinity College, Cambridge, United Kingdom. We thank Louis Leung and Byung C. (Jason) Yoon for invaluable advice in this project, and Sarah Awan for helpful discussion of her preliminary work. We also thank James Blundell, Clare Ellis, Liz Muir, Mansoor Raza, and Kate Wiles for assistance with some of the experiments, and Cláudio Roque for advice on the use of l-azidohomoalanine for monitoring protein synthesis.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Roger Keynes, Anatomy Building, Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. rjk10{at}cam.ac.uk

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Total2322354831
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The Journal of Neuroscience: 32 (25)
Journal of Neuroscience
Vol. 32, Issue 25
20 Jun 2012
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Differing Semaphorin 3A Concentrations Trigger Distinct Signaling Mechanisms in Growth Cone Collapse
Richard P. C. Manns, Geoffrey M. W. Cook, Christine E. Holt, Roger J. Keynes
Journal of Neuroscience 20 June 2012, 32 (25) 8554-8559; DOI: 10.1523/JNEUROSCI.5964-11.2012

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Differing Semaphorin 3A Concentrations Trigger Distinct Signaling Mechanisms in Growth Cone Collapse
Richard P. C. Manns, Geoffrey M. W. Cook, Christine E. Holt, Roger J. Keynes
Journal of Neuroscience 20 June 2012, 32 (25) 8554-8559; DOI: 10.1523/JNEUROSCI.5964-11.2012
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