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Brief Communications

NR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination

Mazen A. Kheirbek, Lindsay Tannenholz and René Hen
Journal of Neuroscience 20 June 2012, 32 (25) 8696-8702; https://doi.org/10.1523/JNEUROSCI.1692-12.2012
Mazen A. Kheirbek
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Lindsay Tannenholz
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René Hen
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1692-12.2012
PubMed 
22723709
Published By 
Society for Neuroscience
History 
  • Received April 10, 2012
  • Accepted May 5, 2012
  • First published June 20, 2012.
  • Version of record published June 20, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/328696-07$15.00/0

Author Information

  1. Mazen A. Kheirbek1,3,
  2. Lindsay Tannenholz2,3, and
  3. René Hen1,2,3
  1. 1Departments of Neuroscience and Psychiatry and
  2. 2Department of Pharmacology, Columbia University, New York, New York 10032, and
  3. 3Division of Integrative Neuroscience, The New York State Psychiatric Institute, New York, New York 10032
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Author contributions

  1. Author contributions: M.A.K. and R.H. designed research; M.A.K. and L.T. performed research; M.A.K. analyzed data; M.A.K. and R.H. wrote the paper.

Disclosures

    • Received April 10, 2012.
    • Accepted May 5, 2012.
  • This work was supported by NIMH Grant 1F32MH092101-01A1 and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (M.A.K.); and NARSAD, the New York Stem Cell Initiative, NIH R01 MH068542, and Hope for Depression Research Foundation grants (R.H.). We thank Liam Drew and Benjamin Samuels for comments on the manuscript and members of the Hen laboratory for discussions on the project. We thank Hannah Moyner for providing the NR2B2lox line; Alex Dranovsky for the NestinCreERT2 line; Helen Scharfman and Colin O'Carroll for assistance with electrophysiological recordings; Amy Radke, Daniel Costantini, and David Doobin for assistance with circuitry analysis and Christine Denny and Michael Drew for input on the NOR task.

  • Correspondence should be addressed to Dr. René Hen, 1051 Riverside Drive, Annex 767, Unit 87, New York, NY 10032. rh95{at}columbia.edu

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Total37626201013
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The Journal of Neuroscience: 32 (25)
Journal of Neuroscience
Vol. 32, Issue 25
20 Jun 2012
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NR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination
Mazen A. Kheirbek, Lindsay Tannenholz, René Hen
Journal of Neuroscience 20 June 2012, 32 (25) 8696-8702; DOI: 10.1523/JNEUROSCI.1692-12.2012

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NR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination
Mazen A. Kheirbek, Lindsay Tannenholz, René Hen
Journal of Neuroscience 20 June 2012, 32 (25) 8696-8702; DOI: 10.1523/JNEUROSCI.1692-12.2012
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