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Articles, Cellular/Molecular

Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System

Marton Lorant Toth, Ilija Melentijevic, Leena Shah, Aatish Bhatia, Kevin Lu, Amish Talwar, Haaris Naji, Carolina Ibanez-Ventoso, Piya Ghose, Angela Jevince, Jian Xue, Laura A. Herndon, Gyan Bhanot, Chris Rongo, David H. Hall and Monica Driscoll
Journal of Neuroscience 27 June 2012, 32 (26) 8778-8790; DOI: https://doi.org/10.1523/JNEUROSCI.1494-11.2012
Marton Lorant Toth
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Ilija Melentijevic
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Leena Shah
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Aatish Bhatia
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Kevin Lu
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Amish Talwar
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Haaris Naji
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Carolina Ibanez-Ventoso
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Piya Ghose
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Angela Jevince
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Jian Xue
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Laura A. Herndon
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Gyan Bhanot
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Chris Rongo
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David H. Hall
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Monica Driscoll
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1494-11.2012
PubMed 
22745480
Published By 
Society for Neuroscience
History 
  • Received March 23, 2011
  • Revision received March 8, 2012
  • Accepted March 20, 2012
  • First published June 27, 2012.
  • Version of record published June 27, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/328778-13$15.00/0

Author Information

  1. Marton Lorant Toth1,
  2. Ilija Melentijevic1,
  3. Leena Shah1,
  4. Aatish Bhatia1,
  5. Kevin Lu1,
  6. Amish Talwar1,
  7. Haaris Naji1,
  8. Carolina Ibanez-Ventoso1,
  9. Piya Ghose2,
  10. Angela Jevince3,
  11. Jian Xue1,
  12. Laura A. Herndon3,
  13. Gyan Bhanot1,
  14. Chris Rongo2,
  15. David H. Hall3, and
  16. Monica Driscoll1
  1. 1Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854,
  2. 2Department of Genetics, Waksman Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, and
  3. 3Center for C. elegans Anatomy, Albert Einstein College of Medicine, Bronx, New York, 10461
View Full Text

Author contributions

  1. Author contributions: M.L.T., D.H.H., and M.D. designed research; M.L.T., I.M., L.S., K.L., A.T., H.N., A.J., and D.H.H. performed research; M.L.T., C.I.-V., P.G., L.A.H., C.R., D.H.H., and J.X. contributed unpublished reagents/analytic tools; M.L.T., A.B., K.L., H.N., G.B., and D.H.H. analyzed data; M.L.T., A.B., D.H.H., and M.D. wrote the paper.

Disclosures

    • Received March 23, 2011.
    • Revision received March 8, 2012.
    • Accepted March 20, 2012.
  • This work was supported by grants from the New Jersey Commission on Spinal Cord Research (M.T. and M.D.) and the National Institutes of Health (AG024882; NS034435, M.D.; OD010943; RFK-IDDRC Grant HD071593, D.H.H.). M.T.T. is currently supported by an American Federation of Aging Research Postdoctoral Fellowship. We thank the Caenorhabditis Genetic Center, supported by NIH NCRR, for providing strains. We also thank S. Shaham for reagents, B. Grant, M. Barr, and E. Vayndorf for critical reading of this manuscript and N. Hall for statistical help for synaptic vesicle data analysis.

  • Correspondence should be addressed to Monica Driscoll, Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, 604 Allison Road, Nelson Biological Laboratories A232, Piscataway, NJ 08854. driscoll{at}biology.rutgers.edu

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AbstractFullPdf
Jun 2012228239110
Jul 20121919183203
Aug 20123486754
Sep 20122735254
Oct 20122385534
Nov 20121633833
Dec 20121172624
Total 20125340460512
Jan 20131226658
Feb 2013995460
Mar 20131359546
Apr 20131054637
May 2013823331
Jun 2013694021
Jul 2013663426
Aug 2013545438
Sep 2013473223
Oct 2013703522
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Total 2013970555420
Jan 2014761322
Feb 2014593420
Mar 2014682618
Apr 2014643628
May 2014513824
Jun 2014574428
Jul 2014654619
Aug 2014462919
Sep 2014464024
Oct 2014513015
Nov 2014522212
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Total 2014682391260
Jan 2015505728
Feb 2015623221
Mar 2015542614
Apr 2015842214
May 2015552220
Jun 2015422424
Jul 2015532221
Aug 2015432114
Sep 2015522520
Oct 2015662126
Nov 2015322512
Dec 2015402119
Total 2015633318233
Jan 2016573024
Feb 2016411923
Mar 2016642426
Apr 201657138
May 2016452816
Jun 2016462511
Jul 2016452922
Aug 201652199
Sep 2016442314
Oct 2016292731
Nov 2016214022
Dec 201693510
Total 2016510312216
Jan 2017124814
Feb 2017134617
Mar 2017196743
Apr 201724942
May 2017128823
Jun 201735810
Jul 2017106224
Aug 201733317
Sep 201710413
Oct 2017113812
Nov 201792912
Dec 201792913
Total 2017113588230
Jan 20188329
Feb 201873311
Mar 2018143616
Apr 20181040823
May 20187989
Jun 20186707
Jul 201891007
Aug 20188659
Sep 20185539
Oct 2018138010
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Total 20181071110135
Jan 2019155515
Feb 2019224915
Mar 2019145930
Apr 201955323
May 2019105518
Jun 201953914
Jul 2019104321
Aug 2019164125
Sep 2019226714
Oct 20191211326
Nov 201973616
Dec 201993110
Total 2019147641227
Jan 2020124818
Feb 2020164222
Mar 2020133329
Apr 202097126
May 2020105127
Jun 202093227
Jul 202032415
Aug 202057415
Sep 202046315
Oct 202049626
Nov 2020104726
Dec 202085215
Total 2020103633261
Jan 2021163739
Feb 202111378
Mar 2021105630
Apr 202184423
May 2021135221
Jun 202173831
Jul 2021103434
Aug 2021177547
Sep 2021125521
Oct 2021175739
Nov 2021153629
Dec 202174814
Total 2021143569336
Jan 2022126125
Feb 202245726
Mar 2022216134
Apr 202267737
May 202234727
Total 202246303149
Total879458802979
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The Journal of Neuroscience: 32 (26)
Journal of Neuroscience
Vol. 32, Issue 26
27 Jun 2012
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Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System
Marton Lorant Toth, Ilija Melentijevic, Leena Shah, Aatish Bhatia, Kevin Lu, Amish Talwar, Haaris Naji, Carolina Ibanez-Ventoso, Piya Ghose, Angela Jevince, Jian Xue, Laura A. Herndon, Gyan Bhanot, Chris Rongo, David H. Hall, Monica Driscoll
Journal of Neuroscience 27 June 2012, 32 (26) 8778-8790; DOI: 10.1523/JNEUROSCI.1494-11.2012

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Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System
Marton Lorant Toth, Ilija Melentijevic, Leena Shah, Aatish Bhatia, Kevin Lu, Amish Talwar, Haaris Naji, Carolina Ibanez-Ventoso, Piya Ghose, Angela Jevince, Jian Xue, Laura A. Herndon, Gyan Bhanot, Chris Rongo, David H. Hall, Monica Driscoll
Journal of Neuroscience 27 June 2012, 32 (26) 8778-8790; DOI: 10.1523/JNEUROSCI.1494-11.2012
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