Article Information
- Received March 19, 2012
- Revision received June 29, 2012
- Accepted July 13, 2012
- First published August 22, 2012.
- Version of record published August 22, 2012.
Author Information
- Deepak P. Srivastava1,7,*,
- Kelly A. Jones1,*,
- Kevin M. Woolfrey1,*,
- Jeffrey Burgdorf4,
- Theron A. Russell1,
- Abigail Kalmbach1,
- Hyerin Lee5,
- Connie Yang5,
- Mazdak M. Bradberry5,
- David Wokosin1,
- Joseph R. Moskal4,
- Manuel F. Casanova6,
- Jack Waters1, and
- Peter Penzes1,2,3
- 1Department of Physiology,
- 2Department of Psychiatry and Behavioral Sciences, and
- 3Lurie Cancer Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611,
- 4Department of Biomedical Engineering and
- 5Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois 60208,
- 6Department of Psychiatry, University of Louisville, Louisville, Kentucky, 40292, and
- 7Department of Neuroscience & Centre for the Cellular Basis of Behaviour, The James Black Centre, Institute of Psychiatry, King's College London, London, SE5 8AF, United Kingdom
Author contributions
Author contributions: D.P.S., K.A.J., K.M.W., and P.P. designed research; D.P.S., K.A.J., K.M.W., J.B., T.A.R., A.K., H.L., C.Y., M.M.B., and J.W. performed research; J.B., D.W., J.R.M., and M.F.C. contributed unpublished reagents/analytic tools; D.P.S., K.A.J., K.M.W., and J.B. analyzed data; D.P.S., K.A.J., K.W., and P.P. wrote the paper.
↵*D.P.S., K.A.J., K.M.W. contributed equally to this work.
Disclosures
- Received March 19, 2012.
- Revision received June 29, 2012.
- Accepted July 13, 2012.
This work was supported by the National Alliance for Autism Research, the National Alliance for Research on Schizophrenia and Depression (NARSAD), the Alzheimer's Association, Brain Research Foundation, and National Institutes of Health (NIH) Grants 2R01MH071316 and 1R01MH097216 (P.P.); a pre-doctoral American Heart Association (AHA) fellowship (K.M.W.); a post-doctoral AHA fellowship, a NARSAD Young Investigators award, and a Royal Society International Exchange Grant (D.P.S.); NIH Grant F31MH085362 (K.A.J.); NIH Grant 1R01MH094835 (J.B.); The Ralph and Marian Falk Medical Research Trust Chicago, IL (J.R.M.); NIH Grants 1R01MH-086784 and 1R01HD-065279 (M.F.C.); NIH Grant 5R21MH085117-02 and a Brain Research Foundation Grant BRF SG 2010-13 (J.W.); and a National Institute of Neurological Disorders and Stroke Grant to the Northwestern University Multi-Photon Core (P30NS054850). EPAC2-null mice were generated by Professor Susumu Seino (Kobe University Graduate School of Medicine). This work was supported by the Northwestern University Behavioral Phenotyping Core, and we thank John Linardakis for assistance with behavioral testing. We thank Katharine R. Smith and Natalie C. Tronson for critical reading of this manuscript.
The authors declare no competing financial interests.
- Correspondence should be addressed to Peter Penzes, Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.p-penzes{at}northwestern.edu
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