Cover legend: Micrograph showing a vertical section through a mouse retina lacking CAST. Horizontal cells, labeled with Calbindin antibodies (green), sprout abnormally into the outer nuclear layer and contact ectopic ribbon synapses stained for RIBEYE (magenta). Labeling of the transcription factor CtBP2 (also magenta) reveals orientation in the retina. For more information, see the article by tom Dieck et al. (pages 12192–12203).