Article Information
- Received January 19, 2012
- Revision received July 9, 2012
- Accepted July 22, 2012
- First published September 5, 2012.
- Version of record published September 5, 2012.
Author Information
- J. Alex Parker1,2,*,
- Rafael P. Vazquez-Manrique1,2,*,
- Cendrine Tourette1,2,
- Francesca Farina1,2,
- Nicolas Offner1,2,
- Arnab Mukhopadhyay3,
- Anne-Marie Orfila1,2,
- Aurélie Darbois1,2,
- Sophie Menet1,2,
- Heidi A. Tissenbaum3, and
- Christian Neri1,2,4
- 1INSERM, Unit 894, Laboratory of Neuronal Cell Biology and Pathology, 75014 Paris, France,
- 2University Paris Descartes, EA 4059, 75014 Paris, France,
- 3Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester Massachusetts 01605, and
- 4Assistance Publique—Hopitaux de Paris (AP-HP), Department of Neurology, Henri Mondor Hospital, 94000 Créteil, France
Author contributions
Author contributions: J.A.P., R.P.V.-M., H.A.T., and C.N. designed research; J.A.P., R.P.V.-M., C.T., F.F., N.O., A.M., A.-M.O., A.D., and S.M. performed research; J.A.P., R.P.V.-M., C.T., N.O., A.M., A.-M.O., A.D., S.M., H.A.T., and C.N. analyzed data; J.A.P., H.A.T., and C.N. wrote the paper.
↵*J.A.P. and R.P.V.-M. contributed equally to this work.
Disclosures
- Received January 19, 2012.
- Revision received July 9, 2012.
- Accepted July 22, 2012.
This project was funded in part by an endowment from the William Randolph Hearst Foundation and a grant (AG025891) from the National Institute of Aging to H.A.T. This work is supported by INSERM, AP-HP, ANR, FRM, and AFM, Paris, France, and by the CHDI Foundation and the Hereditary Disease Foundation. J.A.P. was supported by an Inserm Young Researcher award. H.A.T. is a William Randolph Hearst Young Investigator. We thank Cheryl Wellington and Michael Hayden for constructs encoding htt with 128 Glns, Andrew Fire for C. elegans plasmids, Leonard Guarente for the LG100 strain, Elena Cattaneo for cells from HdhQ111 mice, Robert E. Hughes for constructs encoding SIRT1, and Maryline Mage for technical assistance. Some of the strains were kindly provided by the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health National Center for Research Resources.
- Correspondence should be addressed to Christian Neri, Inserm Unit 894, 2-ter rue d'Alesia, 75014 Paris, France. christian.neri{at}inserm.fr
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