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Articles, Behavioral/Systems/Cognitive

Spatiotemporal Reconfiguration of Large-Scale Brain Functional Networks during Propofol-Induced Loss of Consciousness

Manuel S. Schröter, Victor I. Spoormaker, Anna Schorer, Afra Wohlschläger, Michael Czisch, Eberhard F. Kochs, Claus Zimmer, Bernhard Hemmer, Gerhard Schneider, Denis Jordan and Rüdiger Ilg
Journal of Neuroscience 12 September 2012, 32 (37) 12832-12840; https://doi.org/10.1523/JNEUROSCI.6046-11.2012
Manuel S. Schröter
1Max Planck Institute of Psychiatry, 80804 Munich, Germany,
2Department of Neurology,
3Department of Anesthesiology, and
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Victor I. Spoormaker
1Max Planck Institute of Psychiatry, 80804 Munich, Germany,
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Anna Schorer
2Department of Neurology,
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Afra Wohlschläger
4Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany, and
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Michael Czisch
1Max Planck Institute of Psychiatry, 80804 Munich, Germany,
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Eberhard F. Kochs
3Department of Anesthesiology, and
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Claus Zimmer
4Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany, and
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Bernhard Hemmer
2Department of Neurology,
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Gerhard Schneider
3Department of Anesthesiology, and
5Department of Anesthesiology, Witten/Herdecke University, HELIOS Clinic Wuppertal, 42283 Wuppertal, Germany
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Denis Jordan
3Department of Anesthesiology, and
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Rüdiger Ilg
2Department of Neurology,
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Abstract

Applying graph theoretical analysis of spontaneous BOLD fluctuations in functional magnetic resonance imaging (fMRI), we investigated whole-brain functional connectivity of 11 healthy volunteers during wakefulness and propofol-induced loss of consciousness (PI-LOC). After extraction of regional fMRI time series from 110 cortical and subcortical regions, we applied a maximum overlap discrete wavelet transformation and investigated changes in the brain's intrinsic spatiotemporal organization. During PI-LOC, we observed a breakdown of subcortico-cortical and corticocortical connectivity. Decrease of connectivity was pronounced in thalamocortical connections, whereas no changes were found for connectivity within primary sensory cortices. Graph theoretical analyses revealed significant changes in the degree distribution and local organization metrics of brain functional networks during PI-LOC: compared with a random network, normalized clustering was significantly increased, as was small-worldness. Furthermore we observed a profound decline in long-range connections and a reduction in whole-brain spatiotemporal integration, supporting a topological reconfiguration during PI-LOC. Our findings shed light on the functional significance of intrinsic brain activity as measured by spontaneous BOLD signal fluctuations and help to understand propofol-induced loss of consciousness.

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The Journal of Neuroscience: 32 (37)
Journal of Neuroscience
Vol. 32, Issue 37
12 Sep 2012
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Spatiotemporal Reconfiguration of Large-Scale Brain Functional Networks during Propofol-Induced Loss of Consciousness
Manuel S. Schröter, Victor I. Spoormaker, Anna Schorer, Afra Wohlschläger, Michael Czisch, Eberhard F. Kochs, Claus Zimmer, Bernhard Hemmer, Gerhard Schneider, Denis Jordan, Rüdiger Ilg
Journal of Neuroscience 12 September 2012, 32 (37) 12832-12840; DOI: 10.1523/JNEUROSCI.6046-11.2012

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Spatiotemporal Reconfiguration of Large-Scale Brain Functional Networks during Propofol-Induced Loss of Consciousness
Manuel S. Schröter, Victor I. Spoormaker, Anna Schorer, Afra Wohlschläger, Michael Czisch, Eberhard F. Kochs, Claus Zimmer, Bernhard Hemmer, Gerhard Schneider, Denis Jordan, Rüdiger Ilg
Journal of Neuroscience 12 September 2012, 32 (37) 12832-12840; DOI: 10.1523/JNEUROSCI.6046-11.2012
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