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Mapping Pitch Representation in Neural Ensembles with fMRI

Timothy D. Griffiths and Deborah A. Hall
Journal of Neuroscience 26 September 2012, 32 (39) 13343-13347; https://doi.org/10.1523/JNEUROSCI.3813-12.2012
Timothy D. Griffiths
1Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom,
2Wellcome Trust Centre for NeuroImaging, University College London, London WC1N 3BG, United Kingdom,
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Deborah A. Hall
3National Institute for Health Research Nottingham Hearing Biomedical Research Unit, Nottingham, NG1 5DU, United Kingdom, and
4School of Clinical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom
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    Figure 1.

    Left column, Single-subject macaque BOLD data acquired at 4.7T are shown rendered onto a tilted axial section through the superior temporal plane (top). The macaque auditory core and belt areas defined by tonotopic mapping are outlined in blue and A1 is marked on the right. The BOLD contrast shown is between regular-interval noise at rates above and below the lower limit of pitch in humans. Maxima are demonstrated anterolateral to A1 on either side. The histograms show no clear effect of stimulus rate on BOLD response in the inferior colliculus within the ascending auditory pathway, while mean responses in the cortical maxima increase from 32 Hz (close to the lower limit of pitch in humans). Data acquired by S. Baumann. Right column, Single-subject human BOLD data acquired at 3T are shown rendered onto a tilted axial section through the superior temporal plane (top). Heschl's Gyrus (HG) runs anterolaterally within the plane and the PT is situated behind it. The BOLD contrast shown is between regular-interval noise at rates above and below the lower limit of pitch in humans. No effect of rate on BOLD response is shown in the inferior colliculus while BOLD increases as a function of stimulus rate from 32 Hz. Data acquired by T. Overath.

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    Figure 2.

    Individual subject analysis of fMRI data originally reported by Hall and Plack (2009). The inset shows group-averaged activity for all five pitch-evoking stimuli which encompasses HG (outlined in yellow) and PT (outlined in white). See the text for further explanations of the stimuli. The main panel illustrates those brain regions where there was most consistent pitch-related activity across the five pitch contrasts (i.e., pitch − noise control), within an individual subject. The color scale indicates the degree of consistency, with the associated probability of these spatially overlapping responses occurring by chance (all at p < 0.05). Plane of each axial section is given in MNI (Montreal Neurological Institute) coordinates (mm), with the group-averaged activity represented at z = 10 mm. PP, Planum polare; STS, superior temporal sulcus; IFG, inferior frontal gyrus).

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The Journal of Neuroscience: 32 (39)
Journal of Neuroscience
Vol. 32, Issue 39
26 Sep 2012
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Mapping Pitch Representation in Neural Ensembles with fMRI
Timothy D. Griffiths, Deborah A. Hall
Journal of Neuroscience 26 September 2012, 32 (39) 13343-13347; DOI: 10.1523/JNEUROSCI.3813-12.2012

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Mapping Pitch Representation in Neural Ensembles with fMRI
Timothy D. Griffiths, Deborah A. Hall
Journal of Neuroscience 26 September 2012, 32 (39) 13343-13347; DOI: 10.1523/JNEUROSCI.3813-12.2012
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  • Mapping Human Pitch Representation in a Distributed System Using Depth-Electrode Recordings and Modeling
  • Cortical Mechanisms for Pitch Representation
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