Figure 11. EPSC simulations predict reduced conductance of AMPA receptor-gated channels in V1 versus dlPFC. A1, Mean EPSC of the dlPFC model (red), overlaying the representative EPSC recorded empirically from dlPFC neurons (black, from Fig. 7C). A2, Mean EPSC of the V1 model, using the same ḡAMPA as the dlPFC model (left, blue dotted line), and when reducing ḡAMPA by 69% (right, blue solid line). Model traces overlay the representative EPSC recorded empirically from V1 neurons (gray, from Fig. 7C). A3, Normalized overlay of mean EPSC traces of the dlPFC and low ḡAMPA V1 models. B, Left, EPSC amplitude versus synaptic distance from the soma in the dlPFC model (red filled circles) and V1 model (blue open circles), assuming equal values of ḡAMPA. Right, Log-transformed EPSC amplitudes versus synaptic distance from the soma. The best-fit linear regression of log(amplitude) versus distance is shown in black. C, Cumulative frequency histograms of EPSC amplitudes in the dlPFC and low-ḡAMPA V1 models (1 pA bins; filled red circles and open blue circles, respectively). Cumulative frequency histograms of the dlPFC (black line) and V1 (gray line) empirical data are superimposed. D, EPSCs evoked by activation of each individual synapse on the apical and basal arbors, for the dlPFC and low-ḡAMPA V1 models. Individual EPSCs shown in black; mean EPSC traces shown in color. E, Bar graphs comparing kinetics of EPSCs in dlPFC versus low-ḡAMPA V1 model neurons. Calibration: A, 5 pA/20 ms; D, 5 pA/10 ms. **p < 0.01.