Article Information
- Received February 11, 2012
- Revision received September 7, 2012
- Accepted September 16, 2012
- First published November 21, 2012.
- Version of record published November 21, 2012.
Author Information
- Javier Díaz-Alonso1,2,
- Tania Aguado1,2,
- Chia-Shan Wu3,
- Javier Palazuelos1,2,
- Clementine Hofmann4,5,
- Patricia Garcez6,
- François Guillemot6,
- Hui-Chen Lu3,
- Beat Lutz4,
- Manuel Guzmán1,2, and
- Ismael Galve-Roperh1,2
- 1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
- 2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
- 3The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030,
- 4Institute of Physiological Chemistry, Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany,
- 5Focus Program Translational Neuroscience, Johannes Gutenberg University, 55131 Mainz, Germany, and
- 6Division of Molecular Neurobiology, National Institute of Medical Research, London, NW7 1AA, United Kingdom
Author contributions
Author contributions: J.D.-A., T.A., F.G., M.G., and I.G.-R. designed research; J.D.-A., T.A., C.-S.W., J.P., C.H., and P.G. performed research; J.D.-A., T.A., F.G., H.-C.L., B.L., M.G., and I.G.-R. analyzed data; J.D.-A., H.-C.L., B.L., M.G., and I.G.-R. wrote the paper.
Disclosures
- Received February 11, 2012.
- Revision received September 7, 2012.
- Accepted September 16, 2012.
This work was supported by Ministry of Science and Innovation Grants PLE2009-0117 (I.G-R.) Fundación Alicia Koplowitz (I.G.-R.), and SAF2009-08403 (M.G.), Community of Madrid–Complutense University of Madrid Grants S2011/BMD-2308, S2011/BMD-2336, and 950344 (M.G., I.G.-R.), National Institutes of Health Grants DA029381, HD065561, and NS048884 (H.-C.L.), and German Research Foundation Grant FOR926 (B.L.). J.D.-A. is supported by the Health Research Fund (PFIS), and T.A. and J.P. are supported by the Ministry of Science and Innovation. We are grateful to our collaborators that kindly contributed to this work by sharing reagents and molecular probes. We are also indebted to E. García-Taboada, E. Resel, M. Purrio, and A. Conrad for excellent experimental assistance and to A. González, A. García-Rodríguez, K. Mackie, O. Marín, and J. Ramírez-Franco for valuable comments.
- Correspondence should be addressed to Ismael Galve-Roperh, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain. igr{at}quim.ucm.es
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