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Articles, Development/Plasticity/Repair

The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

Javier Díaz-Alonso, Tania Aguado, Chia-Shan Wu, Javier Palazuelos, Clementine Hofmann, Patricia Garcez, François Guillemot, Hui-Chen Lu, Beat Lutz, Manuel Guzmán and Ismael Galve-Roperh
Journal of Neuroscience 21 November 2012, 32 (47) 16651-16665; https://doi.org/10.1523/JNEUROSCI.0681-12.2012
Javier Díaz-Alonso
1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
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Tania Aguado
1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
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Chia-Shan Wu
3The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030,
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Javier Palazuelos
1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
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Clementine Hofmann
4Institute of Physiological Chemistry, Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany,
5Focus Program Translational Neuroscience, Johannes Gutenberg University, 55131 Mainz, Germany, and
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Patricia Garcez
6Division of Molecular Neurobiology, National Institute of Medical Research, London, NW7 1AA, United Kingdom
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François Guillemot
6Division of Molecular Neurobiology, National Institute of Medical Research, London, NW7 1AA, United Kingdom
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Hui-Chen Lu
3The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030,
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Beat Lutz
4Institute of Physiological Chemistry, Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany,
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Manuel Guzmán
1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
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Ismael Galve-Roperh
1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0681-12.2012
PubMed 
23175820
Published By 
Society for Neuroscience
History 
  • Received February 11, 2012
  • Revision received September 7, 2012
  • Accepted September 16, 2012
  • First published November 21, 2012.
  • Version of record published November 21, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/3216651-15$15.00/0

Author Information

  1. Javier Díaz-Alonso1,2,
  2. Tania Aguado1,2,
  3. Chia-Shan Wu3,
  4. Javier Palazuelos1,2,
  5. Clementine Hofmann4,5,
  6. Patricia Garcez6,
  7. François Guillemot6,
  8. Hui-Chen Lu3,
  9. Beat Lutz4,
  10. Manuel Guzmán1,2, and
  11. Ismael Galve-Roperh1,2
  1. 1Research Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28049 Madrid, Spain,
  2. 2Department of Biochemistry and Molecular Biology I, Ramón y Cajal Institute of Health Research and Neurochemistry Research Institute, Complutense University, 28040 Madrid, Spain,
  3. 3The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030,
  4. 4Institute of Physiological Chemistry, Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany,
  5. 5Focus Program Translational Neuroscience, Johannes Gutenberg University, 55131 Mainz, Germany, and
  6. 6Division of Molecular Neurobiology, National Institute of Medical Research, London, NW7 1AA, United Kingdom
View Full Text

Author contributions

  1. Author contributions: J.D.-A., T.A., F.G., M.G., and I.G.-R. designed research; J.D.-A., T.A., C.-S.W., J.P., C.H., and P.G. performed research; J.D.-A., T.A., F.G., H.-C.L., B.L., M.G., and I.G.-R. analyzed data; J.D.-A., H.-C.L., B.L., M.G., and I.G.-R. wrote the paper.

Disclosures

    • Received February 11, 2012.
    • Revision received September 7, 2012.
    • Accepted September 16, 2012.
  • This work was supported by Ministry of Science and Innovation Grants PLE2009-0117 (I.G-R.) Fundación Alicia Koplowitz (I.G.-R.), and SAF2009-08403 (M.G.), Community of Madrid–Complutense University of Madrid Grants S2011/BMD-2308, S2011/BMD-2336, and 950344 (M.G., I.G.-R.), National Institutes of Health Grants DA029381, HD065561, and NS048884 (H.-C.L.), and German Research Foundation Grant FOR926 (B.L.). J.D.-A. is supported by the Health Research Fund (PFIS), and T.A. and J.P. are supported by the Ministry of Science and Innovation. We are grateful to our collaborators that kindly contributed to this work by sharing reagents and molecular probes. We are also indebted to E. García-Taboada, E. Resel, M. Purrio, and A. Conrad for excellent experimental assistance and to A. González, A. García-Rodríguez, K. Mackie, O. Marín, and J. Ramírez-Franco for valuable comments.

  • Correspondence should be addressed to Ismael Galve-Roperh, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain. igr{at}quim.ucm.es

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The Journal of Neuroscience: 32 (47)
Journal of Neuroscience
Vol. 32, Issue 47
21 Nov 2012
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The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis
Javier Díaz-Alonso, Tania Aguado, Chia-Shan Wu, Javier Palazuelos, Clementine Hofmann, Patricia Garcez, François Guillemot, Hui-Chen Lu, Beat Lutz, Manuel Guzmán, Ismael Galve-Roperh
Journal of Neuroscience 21 November 2012, 32 (47) 16651-16665; DOI: 10.1523/JNEUROSCI.0681-12.2012

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The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis
Javier Díaz-Alonso, Tania Aguado, Chia-Shan Wu, Javier Palazuelos, Clementine Hofmann, Patricia Garcez, François Guillemot, Hui-Chen Lu, Beat Lutz, Manuel Guzmán, Ismael Galve-Roperh
Journal of Neuroscience 21 November 2012, 32 (47) 16651-16665; DOI: 10.1523/JNEUROSCI.0681-12.2012
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