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Featured ArticleArticles, Neurobiology of Disease

Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset

Ofer Pasternak, Carl-Fredrik Westin, Sylvain Bouix, Larry J. Seidman, Jill M. Goldstein, Tsung-Ung W. Woo, Tracey L. Petryshen, Raquelle I. Mesholam-Gately, Robert W. McCarley, Ron Kikinis, Martha E. Shenton and Marek Kubicki
Journal of Neuroscience 28 November 2012, 32 (48) 17365-17372; DOI: https://doi.org/10.1523/JNEUROSCI.2904-12.2012
Ofer Pasternak
1Departments of Psychiatry,
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Carl-Fredrik Westin
2Radiology, and
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Sylvain Bouix
1Departments of Psychiatry,
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Larry J. Seidman
4Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,
6Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114,
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Jill M. Goldstein
1Departments of Psychiatry,
3Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115,
4Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,
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Tsung-Ung W. Woo
5Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,
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Tracey L. Petryshen
6Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114,
7Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts 02142,
8Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02144, and
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Raquelle I. Mesholam-Gately
4Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,
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Robert W. McCarley
4Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,
9Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Massachusetts 02301
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Ron Kikinis
2Radiology, and
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Martha E. Shenton
1Departments of Psychiatry,
9Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Massachusetts 02301
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Marek Kubicki
1Departments of Psychiatry,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2904-12.2012
PubMed 
23197727
Published By 
Society for Neuroscience
History 
  • Received June 18, 2012
  • Revision received August 29, 2012
  • Accepted October 5, 2012
  • First published November 28, 2012.
  • Version of record published November 28, 2012.
Copyright & Usage 
Copyright © 2012 the authors 0270-6474/12/3217365-08$15.00/0

Author Information

  1. Ofer Pasternak1,
  2. Carl-Fredrik Westin2,
  3. Sylvain Bouix1,
  4. Larry J. Seidman4,6,
  5. Jill M. Goldstein1,3,4,
  6. Tsung-Ung W. Woo5,
  7. Tracey L. Petryshen6,7,8,
  8. Raquelle I. Mesholam-Gately4,
  9. Robert W. McCarley4,9,
  10. Ron Kikinis2,
  11. Martha E. Shenton1,9, and
  12. Marek Kubicki1
  1. 1Departments of Psychiatry,
  2. 2Radiology, and
  3. 3Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115,
  4. 4Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,
  5. 5Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478,
  6. 6Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114,
  7. 7Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts 02142,
  8. 8Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02144, and
  9. 9Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Massachusetts 02301
View Full Text

Author contributions

  1. Author contributions: O.P., C.-F.W., L.J.S., J.M.G., T.-U.W.W., T.L.P., R.I.M.-G., R.W.M., R.K., M.E.S., and M.K. designed research; O.P., S.B., T.L.P., R.I.M.-G., M.E.S., and M.K. performed research; O.P., C.-F.W., and S.B. contributed unpublished reagents/analytic tools; O.P. and S.B. analyzed data; O.P., M.E.S., and M.K. wrote the paper.

Disclosures

    • Received June 18, 2012.
    • Revision received August 29, 2012.
    • Accepted October 5, 2012.
  • This work was supported by National Institutes of Health Grants P50-MH080272, R01-MH074794, R01-MH050740, R01-MH082918, P41-RR013218, and M01-RR01032; a Veterans Affairs (VA) merit award, a VA Center grant, and a National Alliance for Research on Schizophrenia and Depression (NARSAD) distinguished investigator grant (M.E.S). O.P. was partly supported by a Fulbright Fellowship (Fulbright Commission for Israel, the United States-Israel Educational Foundation) and by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Ofer Pasternak, Psychiatry Neuroimaging Laboratory, 1249 Boylston Street, Boston MA 02215. ofer{at}bwh.harvard.edu

Statistics from Altmetric.com

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Article usage: November 2012 to March 2021

AbstractFullPdf
Nov 2012134529128
Dec 2012106673147
Total 20122411102275
Jan 20132024348
Feb 20131402638
Mar 20131353544
Apr 2013841936
May 20131003449
Jun 2013733234
Jul 2013482827
Aug 2013343430
Sep 2013453832
Oct 2013663439
Nov 2013512631
Dec 2013191836
Total 2013997367444
Jan 2014222525
Feb 2014232328
Mar 2014512135
Apr 2014503232
May 2014322726
Jun 201422718
Jul 2014261923
Aug 2014281220
Sep 2014361219
Oct 2014521325
Nov 2014261517
Dec 2014221318
Total 2014390219286
Jan 2015182022
Feb 2015353439
Mar 2015381832
Apr 2015332124
May 2015281641
Jun 2015502333
Jul 2015251731
Aug 2015202144
Sep 2015401416
Oct 2015491518
Nov 201525715
Dec 20151012428
Total 2015462230343
Jan 2016512718
Feb 2016331528
Mar 2016411521
Apr 2016432226
May 2016232116
Jun 2016152020
Jul 2016201818
Aug 2016292221
Sep 2016261723
Oct 2016293026
Nov 2016133028
Dec 2016132713
Total 2016336264258
Jan 2017143011
Feb 201712297
Mar 2017233811
Apr 2017193914
May 2017154116
Jun 2017113013
Jul 2017133414
Aug 201751810
Sep 201742517
Oct 20178434
Nov 2017254121
Dec 201762716
Total 2017155395154
Jan 201833411
Feb 2018143111
Mar 2018133315
Apr 2018114211
May 20183296
Jun 201812327
Jul 2018103015
Aug 2018103415
Sep 20186215
Oct 201862820
Nov 2018112113
Dec 201823010
Total 2018101365139
Jan 201971915
Feb 201992913
Mar 2019123817
Apr 2019143525
May 2019124813
Jun 2019103821
Jul 2019213511
Aug 2019217628
Sep 2019235724
Oct 2019238110
Nov 2019124622
Dec 201973813
Total 2019171540212
Jan 202044013
Feb 2020123325
Mar 202093638
Apr 202072223
May 202084323
Jun 2020112422
Jul 202043810
Aug 202092924
Sep 2020124620
Oct 202083514
Nov 2020113718
Dec 2020113219
Total 2020106415249
Jan 202183919
Feb 202163813
Mar 202151612
Total 2021199344
Total514829902404
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The Journal of Neuroscience: 32 (48)
Journal of Neuroscience
Vol. 32, Issue 48
28 Nov 2012
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Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset
Ofer Pasternak, Carl-Fredrik Westin, Sylvain Bouix, Larry J. Seidman, Jill M. Goldstein, Tsung-Ung W. Woo, Tracey L. Petryshen, Raquelle I. Mesholam-Gately, Robert W. McCarley, Ron Kikinis, Martha E. Shenton, Marek Kubicki
Journal of Neuroscience 28 November 2012, 32 (48) 17365-17372; DOI: 10.1523/JNEUROSCI.2904-12.2012

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Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset
Ofer Pasternak, Carl-Fredrik Westin, Sylvain Bouix, Larry J. Seidman, Jill M. Goldstein, Tsung-Ung W. Woo, Tracey L. Petryshen, Raquelle I. Mesholam-Gately, Robert W. McCarley, Ron Kikinis, Martha E. Shenton, Marek Kubicki
Journal of Neuroscience 28 November 2012, 32 (48) 17365-17372; DOI: 10.1523/JNEUROSCI.2904-12.2012
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