Article Information
- Received June 1, 2011
- Revision received December 7, 2011
- Accepted December 14, 2011
- First published February 8, 2012.
- Version of record published February 8, 2012.
Author Information
- Flavia Antonucci1,2,*,
- Alán Alpár3,*,
- Johannes Kacza4,
- Matteo Caleo5,
- Claudia Verderio1,
- Alice Giani1,
- Henrik Martens6,
- Farrukh A. Chaudhry7,
- Manuela Allegra5,
- Jens Grosche8,
- Dominik Michalski9,
- Christian Erck6,
- Anke Hoffmann4,
- Tibor Harkany3,10,
- Michela Matteoli1,11, and
- Wolfgang Härtig8
- 1Department of Medical Pharmacology, CNR Institute of Neuroscience, Università di Milano and
- 2Fondazione Filarete, I-20129 Milan, Italy,
- 3Division of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden,
- 4Institute of Veterinary Anatomy, University of Leipzig, D-04103 Leipzig, Germany,
- 5CNR Institute of Neuroscience, I-51600 Pisa, Italy,
- 6Synaptic Systems GmbH, D-37079 Göttingen, Germany,
- 7The Biotechnology Centre of Oslo & Centre for Molecular Biology and Neuroscience, University of Oslo, N-0317 Oslo, Norway,
- 8Paul Flechsig Institute for Brain Research, University of Leipzig, D-04109 Leipzig, Germany,
- 9Department of Neurology, University of Leipzig, D-04103 Leipzig, Germany,
- 10European Neuroscience Institute, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom, and
- 11Instituto Clinico Humanitas, IRCCS, Rozzano, I-20089 Milan, Italy
Author contributions
Author contributions: A.A., C.V., T.H., M.M., and W.H. designed research; F.A., A.A., J.K., M.C., C.V., A.G., H.M., D.M., M.A., J.G., A.H., and W.H. performed research; M.C., F.A.C., H.M., and C.E. contributed unpublished reagents/analytic tools; F.A., M.C., J.G., and W.H. analyzed data; A.A., T.H., M.M., and W.H. wrote the paper.
↵*F.A. and A.A. contributed equally to this work.
Disclosures
- Received June 1, 2011.
- Revision received December 7, 2011.
- Accepted December 14, 2011.
This work was supported by the European Union 7th Framework Program Grants HEALTH-F2-2009-241498 (EUROSPIN, M.M., H.M.) and HEALTH-F2-2007-201159 (MEMOLOAD, T.H.), the Scottish Universities Life Science Alliance (A.A., T.H.), National Institutes of Health (DA023214, T.H.), the Swedish Research Council (T.H.), Compagnia di San Paolo, Torino, Italy (M.M., M.C.), PRIN 2008 2008T4ZCNL (M.M.), and Cariplo 2998–3184 (M.M.). We thank Jean-Marc Fritschy, Wolfgang H. Oertel, Hiroyuki Hioki, Michele Solimena and Masahiko Watanabe for antibodies. The technical assistance provided by Matthias Böddener, Ute Bauer, Marita Heindl, Gabriele Lindner and Orsolya Penz is gratefully acknowledged.
The authors declare no competing financial interests.
- Correspondence should be addressed to either of the following: Tibor Harkany, Division of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Scheeles väg 1:A1, Karolinska Institutet, S-17177 Stockholm, Sweden, Tibor.Harkany{at}ki.se; or Michela Matteoli, Department of Medical Pharmacology, CNR Institute of Neuroscience, University of Milan, I-20129 Milan, Italy, michela.matteoli{at}unimi.it
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