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Cover legend: Spontaneous activity is common in neural systems and poses a challenge to detecting and discriminating signals. In the locust olfactory system, noisy, spontaneous activity originates in olfactory receptor neurons of the antenna. This activity first propagates and is then reduced in two stages of neural processing. Photo by Stacey Brown Daffron. For more information, see the article by Joseph et al. (pages 2900–2910).