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Articles, Development/Plasticity/Repair

SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

Samantha M. Lloyd-Burton, Elisa M. York, Mohammad A. Anwar, Adele J. Vincent and A. Jane Roskams
Journal of Neuroscience 6 March 2013, 33 (10) 4468-4481; https://doi.org/10.1523/JNEUROSCI.3585-12.2013
Samantha M. Lloyd-Burton
1Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada and
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Elisa M. York
1Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada and
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Mohammad A. Anwar
1Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada and
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Adele J. Vincent
2Menzies Research Institute, University of Tasmania, Hobart, TAS 7000, Australia
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A. Jane Roskams
1Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3585-12.2013
PubMed 
23467362
Published By 
Society for Neuroscience
History 
  • Received July 26, 2012
  • Revision received January 22, 2013
  • Accepted January 25, 2013
  • First published March 6, 2013.
  • Version of record published March 6, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/334468-14$15.00/0

Author Information

  1. Samantha M. Lloyd-Burton1,
  2. Elisa M. York1,
  3. Mohammad A. Anwar1,
  4. Adele J. Vincent2, and
  5. A. Jane Roskams1
  1. 1Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada and
  2. 2Menzies Research Institute, University of Tasmania, Hobart, TAS 7000, Australia
View Full Text

Author contributions

  1. Author contributions: S.M.L.-B. and A.J.R. designed research; S.M.L.-B., E.M.Y., M.A.A., A.J.V., and A.J.R. performed research; A.J.R. contributed unpublished reagents/analytic tools; S.M.L.-B., E.M.Y., M.A.A., and A.J.R. analyzed data; S.M.L.-B., E.M.Y., and A.J.R. wrote the paper.

Disclosures

    • Received July 26, 2012.
    • Revision received January 22, 2013.
    • Accepted January 25, 2013.
  • This work is supported by Canadian Institutes of Health Research MOP-89739, Michael Smith Foundation for Health Research Senior Scholar Award (A.J.R.), and MS Canada Postdoctoral Fellowship (S.M.L.-.B.). We thank Kathryn Westendorf for technical assistance and expertise, and our awesome high school volunteer, Antigone (Tiggy) Valen, for her help in quantification, and Gavin Bock for assistance with behavioral analysis. We would also like to thank Khatereh Aminoltejari and Greg Silasi (from the lab of Dr. Tim Murphy, University of British Columbia) for their immense help in teaching us and troubleshooting rose bengal lesion and behavioral analysis. We would also like to thank Dr. Helene Sage for sharing reagents and insight into SPARC action, and Drs. Tim Murphy, Wolfram Tetzlaff, and Brian MacVicar for their collaboration and their insightful discussions of this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. A. Jane Roskams, Room 3-309 Life Sciences Institute, University of British Columbia, 2350 Health Sciences Boulevard, Vancouver, BC V6T 1Z4, Canada. roskams{at}zoology.ubc.ca

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Jan 201852616
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Feb 2025145025
Mar 202536944
Apr 202522521
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Jun 20255104
Total 202535245138
Total38231151240
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The Journal of Neuroscience: 33 (10)
Journal of Neuroscience
Vol. 33, Issue 10
6 Mar 2013
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SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia
Samantha M. Lloyd-Burton, Elisa M. York, Mohammad A. Anwar, Adele J. Vincent, A. Jane Roskams
Journal of Neuroscience 6 March 2013, 33 (10) 4468-4481; DOI: 10.1523/JNEUROSCI.3585-12.2013

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SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia
Samantha M. Lloyd-Burton, Elisa M. York, Mohammad A. Anwar, Adele J. Vincent, A. Jane Roskams
Journal of Neuroscience 6 March 2013, 33 (10) 4468-4481; DOI: 10.1523/JNEUROSCI.3585-12.2013
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