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Articles, Development/Plasticity/Repair

Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum

Estuardo Robles, Alessandro Filosa and Herwig Baier
Journal of Neuroscience 13 March 2013, 33 (11) 5027-5039; DOI: https://doi.org/10.1523/JNEUROSCI.4990-12.2013
Estuardo Robles
1Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany, and 2Department of Physiology, University of California, San Francisco, San Francisco, California 94158
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Alessandro Filosa
1Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany, and 2Department of Physiology, University of California, San Francisco, San Francisco, California 94158
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Herwig Baier
1Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany, and 2Department of Physiology, University of California, San Francisco, San Francisco, California 94158
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Abstract

The axons of retinal ganglion cells (RGCs) form topographic connections in the optic tectum, recreating a two-dimensional map of the visual field in the midbrain. RGC axons are also targeted to specific positions along the laminar axis of the tectum. Understanding the sensory transformations performed by the tectum requires identification of the rules that control the formation of synaptic laminae by RGC axons. However, there is little information regarding the spatial relationships between multiple axons as they establish laminar and retinotopic arborization fields within the same region of neuropil. Moreover, the contribution of RGC axon lamination to the processing of visual information is unknown. We used Brainbow genetic labeling to visualize groups of individually identifiable axons during the assembly of a precise laminar map in the larval zebrafish tectum. Live imaging of multiple RGCs revealed that axons target specific sublaminar positions during initial innervation and maintain their relative laminar positions throughout early larval development, ruling out a model for lamina selection based on iterative refinements. During this period of laminar stability, RGC arbors undergo structural rearrangements that shift their relative retinotopic positions. Analysis of cell-type-specific lamination patterns revealed that distinct combinations of RGCs converge to form each sublamina, and this input heterogeneity correlates with different functional responses to visual stimuli. These findings suggest that lamina-specific sorting of retinal inputs provides an anatomical blueprint for the integration of visual features in the tectum.

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The Journal of Neuroscience: 33 (11)
Journal of Neuroscience
Vol. 33, Issue 11
13 Mar 2013
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Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum
Estuardo Robles, Alessandro Filosa, Herwig Baier
Journal of Neuroscience 13 March 2013, 33 (11) 5027-5039; DOI: 10.1523/JNEUROSCI.4990-12.2013

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Precise Lamination of Retinal Axons Generates Multiple Parallel Input Pathways in the Tectum
Estuardo Robles, Alessandro Filosa, Herwig Baier
Journal of Neuroscience 13 March 2013, 33 (11) 5027-5039; DOI: 10.1523/JNEUROSCI.4990-12.2013
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