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Articles, Cellular/Molecular

Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling

Graziana Gatto, Irina Dudanova, Philipp Suetterlin, Alun M. Davies, Uwe Drescher, John L. Bixby and Rüdiger Klein
Journal of Neuroscience 20 March 2013, 33 (12) 5399-5410; DOI: https://doi.org/10.1523/JNEUROSCI.4707-12.2013
Graziana Gatto
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152, Martinsried, Germany,
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Irina Dudanova
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152, Martinsried, Germany,
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Philipp Suetterlin
2Medical Research Council Centre for Developmental Neurobiology, King's College London, SE1 1UL, London, United Kingdom,
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Alun M. Davies
3School of Biosciences, CF10 3AT, Cardiff, United Kingdom, and
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Uwe Drescher
2Medical Research Council Centre for Developmental Neurobiology, King's College London, SE1 1UL, London, United Kingdom,
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John L. Bixby
4Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136
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Rüdiger Klein
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152, Martinsried, Germany,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4707-12.2013
PubMed 
23516305
Published By 
Society for Neuroscience
History 
  • Received October 4, 2012
  • Revision received January 17, 2013
  • Accepted February 12, 2013
  • First published March 20, 2013.
  • Version of record published March 20, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/335399-12$15.00/0

Author Information

  1. Graziana Gatto1,
  2. Irina Dudanova1,
  3. Philipp Suetterlin2,
  4. Alun M. Davies3,
  5. Uwe Drescher2,
  6. John L. Bixby4, and
  7. Rüdiger Klein1
  1. 1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152, Martinsried, Germany,
  2. 2Medical Research Council Centre for Developmental Neurobiology, King's College London, SE1 1UL, London, United Kingdom,
  3. 3School of Biosciences, CF10 3AT, Cardiff, United Kingdom, and
  4. 4Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136
View Full Text

Author contributions

  1. Author contributions: G.G., A.M.D., U.D., and R.K. designed research; G.G., I.D., and P.S. performed research; J.L.B. contributed unpublished reagents/analytic tools; G.G., I.D., P.S., and U.D. analyzed data; G.G., J.L.B., and R.K. wrote the paper.

View Abstract

Disclosures

    • Received October 4, 2012.
    • Revision received January 17, 2013.
    • Accepted February 12, 2013.
  • This study was supported by the Max Planck Society, the European Union [MOLPARK (Molecular mechanisms of neuronal restoration: novel approaches for Parkinson's disease)], the German Research Foundation (Collaborative Research Centre 870), the National Institutes of Health, and the Wellcome Trust. We thank L. Gaitanos for technical assistance, D. Marinescu and S. Krinner for mouse genotyping, A. Huber-Brösamle, T. Matozaki, and Eek-hoon Jho for kindly providing reagents, and T. Gaitanos, P. Klein, and S. Paixão for fruitful discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Rüdiger Klein, Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Am Klopferspitz 18A, D-82152, Martinsried, Germany. rklein{at}neuro.mpg.de

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AbstractFullPdf
Mar 20131932101162
Apr 20134357267
May 20131095635
Jun 20131075335
Jul 2013494215
Aug 2013421914
Sep 2013722822
Oct 2013723235
Nov 2013532219
Dec 2013543125
Total 20132925456429
Jan 2014513632
Feb 2014323022
Mar 2014532413
Apr 2014231929
May 201433218
Jun 201422238
Jul 2014432811
Aug 2014171615
Sep 201446147
Oct 201427128
Nov 201412108
Dec 201421115
Total 2014380244166
Jan 201518258
Feb 201524129
Mar 2015312017
Apr 20151477
May 20157266
Jun 201551615
Jul 20155913
Aug 20159108
Sep 201533389
Oct 2015141312
Nov 201520710
Dec 20151087
Total 2015190191121
Jan 20161569
Feb 2016141114
Mar 20161486
Apr 20161668
May 20161044
Jun 20167119
Jul 2016261114
Aug 201619116
Sep 20161688
Oct 20161883
Nov 2016162110
Dec 20161144
Total 201617211995
Jan 20176318
Feb 20176282
Mar 20174193
Apr 20176257
May 20178204
Jun 2017493
Jul 20170121
Aug 20173111
Sep 20173163
Oct 20172122
Nov 20175171
Dec 20173102
Total 20175021037
Jan 20184235
Feb 20184123
Mar 20183152
Apr 20180201
May 20183171
Jun 20181223
Jul 20183204
Aug 20180205
Sep 20183214
Oct 20180442
Nov 20185473
Dec 20181151
Total 20182727634
Jan 20195218
Feb 20193285
Mar 20196134
Apr 2019187
May 20193156
Jun 20193134
Jul 20190139
Aug 20190173
Sep 2019636
Oct 2019386
Nov 201902011
Dec 20195126
Total 20193517175
Jan 2020277
Feb 2020075
Mar 202011713
Apr 20202159
May 20203138
Jun 2020156
Jul 2020152
Aug 2020146
Sep 20202122
Oct 20204167
Nov 20203145
Dec 20203165
Total 20202313175
Jan 202131112
Total 202131112
Total380518091044
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The Journal of Neuroscience: 33 (12)
Journal of Neuroscience
Vol. 33, Issue 12
20 Mar 2013
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Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling
Graziana Gatto, Irina Dudanova, Philipp Suetterlin, Alun M. Davies, Uwe Drescher, John L. Bixby, Rüdiger Klein
Journal of Neuroscience 20 March 2013, 33 (12) 5399-5410; DOI: 10.1523/JNEUROSCI.4707-12.2013

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Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling
Graziana Gatto, Irina Dudanova, Philipp Suetterlin, Alun M. Davies, Uwe Drescher, John L. Bixby, Rüdiger Klein
Journal of Neuroscience 20 March 2013, 33 (12) 5399-5410; DOI: 10.1523/JNEUROSCI.4707-12.2013
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